Bone Abstracts

Recently, Y1 receptor (Y1R) has arisen as a potential regulator in the local control of bone turnover. BIBP3226 is a potent Y1R selective antagonist that was successfully used in in vitro studies showing a positive impact in the benefit of bone turnover, thus providing good perspectives for its use as a pharmacological tool for bone regeneration.However, BIBP3226 behaviour in a complex milieu such as the bone compartment is unknown. As drugs can...

Biological calcification is a regulated process in which different types of tissues, cells and biomolecules participate in the coordination and regulation of the metabolic events involved in accumulating large amounts of calcium phosphate. This process could be speeded up using carbon nanotubes (CNTs) systems. The objective of our study was to compare cell growth and formation of mineralized matrix nodules by osteoblasts grown in plastic and in titanium (Ti) discs surfaces. Th...

Introduction: Normal mechanical loading potently induces bone formation via effects on osteocytes. Current investigations of mechanical loading of bone do not reflect the interactions of the cells within it, mostly focusing on mechanical loading of osteoblasts in monolayers. Existing 3D models do not elucidate the osteoblast-osteocyte interactions that regulate mechanically-induced bone formation. We developed a novel in vitro 3D co-culture model of bone1 t...

Osteoporosis-related hip fractures represent a substantial cause of mortality and morbidity in industrialized countries; nonetheless, past studies in Austria lack mortality figures save during hospitalization (in-hospital mortality).We therefore retrospectively retrieved pseudonymized invoice data from Austrian social insurance authorities covering roughly 98% of the entire population including 31 548 subjects over 51 years of age who sustained first hip...

Osteoporosis is commonly known as the prime risk factor for hip fracture in the elderly. We thus evaluated status and effect of osteoporosis treatment amongst hip fracture patients in a large Austrian cohort.Retrospectively retrieved pseudonymized invoice data from Austrian social insurance authorities covering roughly 98% of the entire population included 31 548 subjects over 50 years with first hip fractures between July 2008 and December 2010, with fo...

Background: Bone marrow edema (BME) is a localised bone lesion. We hypothesize that structural bone alterations increase the susceptibility to BME. Aim of this study was to analyse bone micro structure, bone mineral density (BMD) and serum fasting bone turnover marker (BTM) values in patients with BME.Methods: We compared 14 nonosteoporotic patients (43.7±19.2 years) with atraumatic BME of lower limb to 35 age-matched healthy controls (HC). HR-pQCT ...

Introduction: Atypical markers will provide interesting information in order to assess the bone metabolism. Serotonin has a dual action related to the bone and its serum level is the easiest to use in daily clinical practice also the exact value is not very well described up to this moment.Aim: We correlate to serum levels of serotonin with different results of clinical bone health evaluation in menopausal women.Materials and metho...

A healthy 8-year-old girl of Nigerian origin, presented in January 2014 with a 2 month history of progressive pain and swelling of the right 2nd, 3rd and 4th toe. There was no preceding trauma or illness. Those toes were swollen, tender and cold to touch, with bluish skin discoloration (Figure 1).She had normal peripheral pulses. Her inflammatory markers were normal, as was haemoglobin electrophoresis. A Doppler ultrasoun...

Introduction: Obstructive sleep apnea (OSA) is a common sleep-related respiratory disorder characterized by repeated episodes of apnea and hypopnea resulting in sleep fragmentation, nocturnal hypoxia and hypercapnia, and excessive daytime sleepiness. OSA has recently become a well-recognized problem in view of its high prevalence in the general population. OSA is associated with many endocrine disorders (hypogonadotropic hypogonadism, hypercortisolism, glucose intolerance). Th...

Background: Atypical Femur Fracture (AFF) has become widely reported as a complication of bisphosphonate therapy in adults since the first case report in 2005. A trend towards a similar pattern of fractures has been reported in children in Sheffield in 2012. A 13 year old boy was reported in 2014 with an ‘AFF’ of the tibia but that fracture did not meet the standard diagnostic criteria of AFF. Last year a 16-year-old girl treated with pamidronate for idiopathic juven...