Bone Abstracts

Recessive osteogenesis imperfecta (OI) is caused by mutations in genes encoding proteins involved in post-translational interactions with type I collagen. A founder mutation in a new gene responsible for recessive OI has recently been reported in Bedouins from Israel and Saudi Arabia, who have a homozygous deletion of TMEM38B exon 4 and surrounding intronic sequence. TMEM38B encodes TRIC-B, an integral ER membrane monovalent cation channel involved in Ca...

Introduction: Insulin sensitising agents are reported to have a diverse range of effects on bone with metformin exerting positive effects and thiazolidinenediones (TZDs) exerting negative effects. 5’AMP-activated protein kinase (AMPK) plays a critical role in cellular energy homeostasis. It is widely expressed in the body and can be activated by metformin.Objective:: We investigated the role of AMPK pathway in mediating the effects of metformin on t...

Objectives: Obese adults commonly have vitamin D deficiency and secondary hyperparathyroidism prior to bariatric surgery. Whether similar metabolic abnormalities exist in morbidly obese adolescents is not known. This study investigated the prevalence of vitamin D deficiency and evaluated the relationship between vitamin D and parathyroid hormone (PTH) in morbidly obese adolescents undergoing evaluation for bariatric surgery.Methods: A cross-sectional stu...

Objective: To examine the outcomes and costs of direct medical care for falls in elderly women in Lithuania.Methods: Women aged 65 years and older, who visited National Osteoporosis Center for diagnostic or treatment procedures. Thereafter a telephone survey was performed using the questionnaire with 28 questions about the number, circumstances, and consequences of falls. The cost of health care due to fall was estimated after calculating the sum of cost...

Objective: To evaluate the changes of health-related quality of life (HRQoL) 36 months after fracture in patients from Lithuania following vertebral or forearm fractures.Material and methods: Patients aged 50 years and older, with low energy trauma clinical vertebral fracture (VFx) or distal forearm fracture (FFx), enrolled and observed for 18 months in the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) in Lithuania, w...

The present study introduces in silico analysis of osteoporotic lumbar vertebrae L1 due to dynamic compressive load.Objective: To define the reduction of load carrying capacity caused by various grades of osteoporosis.Materials and methods: The three-dimensional inhomogeneous continuum problem was formulated for simulation purposes. The L1 vertebra model consists of cortical shell, trabecular network and poste...

Objective: To investigate the relationship of frailty with vitamin D in community dwelling elderly women.Materials and methods: A retrospective cross-sectional study was performed on women over 60 years who were not using vitamin D supplementations. Frailty status was defined using Fried’s criteria: weakness, low walking speed, low physical activity, weight loss, exhaustion. Participants were classified as robust, prefrail and frail if they scored 0...

Objective: To assess the incidence and distribution of hip fractures by sex and age among individuals over 40 years in Lithuania in 2010.Materials and methods: This population-based study was performed collecting the data from all orthopaedic-traumatology inpatient departments in Lithuania. The case histories of Lithuanian residents over 40 years, who had suffered a hip fracture in 2010, were examined. Subjects with primary hip fracture (ICD-10 codes S72...

The femoral neck fractures (FNF) are one of the most common non-traumatic fractures in elderly people. Frequently the patients with fractures of this localization need surgical treatment and long-term rehabilitation. It’s widely known that FNF in patients with rheumatoid arthritis (RA) occur more often than in the population.Background: To determine the frequency of FNF in patients with RA and to characterize the patients with RA and with FNF at the...

Apart from analyses of well-known correlates of age-related hip fracture risk, such as low BMD, impaired external geometry and deteriorated micro-architecture, there is increasing interest to elucidate nano-structural determinants of fracture risk at the bone mineralized matrix level.In this study we analyzed cortical bone specimens of the femoral neck region in five elderly women who sustained hip fracture and in four healthy women of corresponding age....