Bone Abstracts

Background: The ‘adequate’ level of 25-hydroxyvitamin D (25OHD) in children remains unclear. For bone outcomes, parathyroid hormone (PTH) is an important functional biomarker. Prior studies have shown too weak a correlation between 25OHD and PTH levels to determine adequate 25OHD level.Objective: To determine adequate 25OHD level(s) in children using a normal PTH value of 65 pg/ml while adjusting for calcium intake.Design...

Osteogenesis imperfecta is a clinically heterogeneous heritable connective tissue disorder. Most OI cases are due to mutations in type I collagen genes, COL1A1 and COL1A2 encoding the pro-alpha1(I) and pro-alpha2(I) chains respectively. However, genotype–phenotype correlation has not been completely elucidated yet. In this study we evaluated a familial case including a mother and a daughter, classified as OI type I. The daughter had more severe clinical ...

Introduction: For the very first time were assessed in vivo the metabolic and lipid profiles of osteocytes. During menopause period the appearance of an osteoporotic condition can be associated with an overall metabolic decline in bone cells, as well an increase of reactive oxygen species (ROS), and we hypothesized that it is mainly attributed to osteocytes metabolic and lipid changes, which could be apparently attenuated after raising blood estradiol (E2) levels. To ...

Circulating microRNAs (miRNAs) are currently being investigated as novel biomarkers for osteoporosis and osteoporotic fractures. The aim of the present study was to investigate the differential expression of specific circulating micro RNAs known to regulate bone metabolism and homeostasis in postmenopausal osteoporotic women with and without vertebral fractures. For the analysis, miRNAs were isolated from the serum of 24 osteoporotic patients with at least one moderate vertebr...

Circulating microRNAs (miRNAs) are currently being investigated as novel biomarkers for osteoporosis and osteoporotic fractures. The aim of the present study was to investigate the differential expression of specific circulating micro RNAs known to regulate bone metabolism and homeostasis in postmenopausal osteoporotic women with and without vertebral fractures. For the analysis, miRNAs were isolated from the serum of 24 osteoporotic patients with at least one moderate vertebr...

Introduction: The clinical diagnosis of mild forms of hypophosphatasia [HPP], a rare genetic bone disease, is often made in adulthood, on the basis of persistently low serum levels of alkaline phosphatase [ALP], often coupled with signs of poor bone/teeth mineralization.Case report: A 50-year-old male on treatment with vitamin D supplementation because of osteoporosis of lumbar spine (T-score –3.2) and femoral neck (T-score –2.4), was referred ...

The P2Y2 receptor is a G-protein-coupled receptor and the natural ligands (ATP/UTP) strongly inhibit mineralized bone nodule formation by osteoblasts in vitro. We have earlier shown that overexpression of the P2Y2 receptor in vivo resulted in decreased bone mineral density (BMD), partially due to increased bone resorption, but also decreased formation (detected by serum bone markers and bone histomorphometry).This ...

Transient paralysis by a single injection of botulinum toxin type A (Botox) in rodents has been shown to cause local bone loss of the affected leg. The animals regain function of the leg within 3–4 weeks and bone loss slowly recovers. The duration of the paralysis is dose-dependent. However, higher doses of Botox cause weight loss and decreased activity level.Aim of study was to investigate whether repeated injections of low-dose Botox could induce ...

Leptin and adiponectin have an opposing relationship in circulation; leptin is higher and adiponectin lower in overweight/obese individuals, and vice versa. Studies showed that both leptin and adiponectin can be either beneficial or harmful to bone depending on the mode of action. The objective was to investigate the association of serum leptin:adiponectin ratio (L:A) with BMD of various skeletal sites and markers of bone turnover in overweight and obese postmenopausa...

The connection between osteoporosis and obesity is becoming a topic of increasing research. The adipocyte-secreted hormones, leptin and adiponectin, may be the mediators between adipose tissue and bone. The aim was to examine the changes in leptin and adiponectin with the weight and body composition (fat and lean mass) change during the 6-months weight loss program. Additionally, the relationship between two adipokines and BMD of various skeletal sites was also examined. Parti...