Bone Abstracts

IκB Kinase β (IKKβ), a key component of NFκB signaling, plays an important role in bone disease and cancer. Genetic and pharmacological inhibition of IKKβ/NFκB signaling increase bone mass and protect against ovariectomy- and inflammation-induced bone loss. Here, we describe a previously unknown role of the IKKβ/FoxO3a axis in bone metastasis associated with breast cancer. We observed that IKKβ expression is prevalent in invasive breast ...

The gap between osteoporosis clinical guidelines and their implementation exists in all countries. The increasing use of computerised patient records offers new opportunities to aide clinical decision making. We have developed a fracture and osteoporosis investigation and treatment clinical decision tool to aide primary care management of osteoporosis. Uniquely, this tool is designed to be integrated with existing patient data software.Electronic clinica...

In the recent years, worldwide the FRAX algorithm is used more extensively to estimate the risk of fragility fractures. Since 2009, the Ukrainian Scientific Medical Centre on Osteoporosis has been extensively using the FRAX algorithm to estimate the fragility fracture risk.The aim of the study was to establish the normative data for the Austrian model of FRAX algorithm. We examined 3405 women aged 40–89. For the statistical analysis of results the S...

Osteogenesis imperfecta (OI) is a genetic disorder of increased bone fragility and other connective tissue manifestations with a wide spectrum of clinical expressions. Even though the main problems come from the skeleton, we have to make an overall examination including skeletal deformities, joints and muscles, hearing, sight, teeth, heart, lungs and gastrointestinal organs to establish optimal follow up guidelines for people with OI. These examinations should then provide the...

No treatment for osteoporosis abolishes the risk of fracture. Even under the ‘ideal’ conditions of adherence and monitoring, in the controlled pivotal trials, a significant proportion of individuals receiving the active drug still suffer new fractures. In everyday practice the situation is even more challenging. Adherence to medication is poor, patients are often older than in trials, or suffer from a number of comorbidities that could have excluded them from the ori...

Introduction: Pregnancy- and lactation-associated osteoporosis (PLO) is an uncommon disease. The majority of cases are seen in the third trimester or early post-partum in the primagravid women and the prominent clinical feature of PLO is the severe and prolonged back pain and height loss. To date the prevalence and the aetiology of this disorder are unclear and there are no guidelines for its treatment.Case report: We report the outcomes of teri...

Bone damage is one of the main unfavourable health effects of chronic exposure to cadmium (Cd). This heavy metal stimulates osteoclastic bone resorption and inhibits osteoblastic bone formation resulting in decreased bone mineralization and as a result weakening of the bone biomechanical properties. Recently, using a rat model of chronic human exposure to cadmium, we have revealed that even low exposure to this metal may increase bone vulnerability to fracture. Taking into acc...

We have previously demonstrated the presence of circulating mesenchymal stem cells (MSCs) in fracture patients. However, the exact time for their appearance in circulation remains unknown. Nine patients (five females, four males, age 70±12 years, range 55–89 years) with a fresh femoral neck fracture were recruited in the study, which was approved by the local ethical committee. Bone marrow (BM) sample drawn from the iliac crest of all patients served as the individua...

The clinical orthopaedic problem of delayed healing or non-union after complex fractures affects 5–10% of all patients, especially within the elderly population. Recently several in vitro studies showed that CD133+ cells bare angiogenic capacities and contribute to a better outcome concerning ischemia induced angiogenesis in vivo. A local administration of these specific cells to the fracture gap appears feasible as a new treatment option for biological ...

Background: Scoliosis is lateral curvature of the spine ≥10°, as measured on standing spinal radiographs. There are no published studies that have investigated determinants of scoliosis using a prospective cohort design, making the establishment of cause and effect difficult. Several large population-based cohorts exist throughout the world with a wide range of data already collected, and while spinal imaging with radiographs is not generally collected in these coho...