Bone Abstracts

Objectives: CKD in children is associated with suppressed body growth. Physical activity has been previously shown to increase expression of IGF1 signaling in muscles of rats with CKD, but the effects of this intervention on bone tissue have not been investigated yet. The purpose of this study was to examine the effects of aerobic exercise on CKD related bone disease.Methods: Twenty-day old/50 g male rats underwent a two step subtotal nephrectomy (Nx) or...

Introduction: Osteogenesis imperfecta (OI) is characterized by low bone mass, skeletal fragility and, frequently, short stature. We previously showed in oim/oim mice that sclerostin inhibition increased bone mass, mineral content and strength. Here, we compared the body length and the sizes of long bones, head and vertebrae between oim/oim and wildtype mice and analyzed the effect of sclerostin antibody (Scl-Ab) on these parameters.Materials and methods:...

Objectives: A role for the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) in controlling bone mass and strength has previously been reported. However, lack of one gut hormone is compensated by an elevated sensitivity to the other in single receptor knockout mice. As such the exact role of GIP and GLP-1 in bone is unclear. The aims of the present study were to assess bone mass and strength in mice with functional deletion of ...

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Objectives: Most osteolytic tumors are in fact mixed and contain an osteoblastic component associated with the predominant osteolytic areas. This metaplastic woven bone can be evidenced on X-rays as blurred white areas but is always evidenced by histological analysis even in the absence of radiological expression. Metaplastic bone formation reflects the activation of new osteoblasts, the stimulation of the dormant lining cells due to the release of growth factors buried in the...

Purpose: To determine the association between socio-economic status (SES) and risk of hip fracture.Methods: Retrospective cohort study. We used a population database which contains primary care and hospital inpatient records of over >5 million people. Anyone registered in this database in 2009–2012 and resident in an urban area was eligible. Main measures: a validated SES composite index (accounting for proportion of unemployed, insufficiently e...

Purpose: To determine whether and which co-morbidities (amongst those included in the Charlson co-morbidity index) confer an increased risk of hip fracture amongst elderly men.Methods: We conducted a population-based cohort study using a population database which contains primary care and hospital inpatient records of over >2 million people. All men aged ≥65 years registered on 1/1/2007 were followed up until 31/12/2009. Both exposure (co-morbi...

Introduction: Children with chronic kidney disease (CKD) who suffer from growth retardation have usually normal circulating GH but low IGF1, suggesting GH resistance. We have previously shown in growth retarded CKD rats an increase in suppressor of cytokine signaling 2 (SOCS2) levels, a key negative regulator of GH signaling. SOCS2 spontaneously mutated (HG) mice show an exaggerated body growth and increased bone mass. We investigated growth and GH receptor (GHR) signaling in ...

Improvements on the overall cure rates for childhood acute lymphoblastic leukemia (ALL) have allowed the cure of over 85% of treated patients. At least 70% of survivors of childhood ALL cancers have substantial morbidities as a result of their treatment. Long term musculoskeletal complications in this population are currently receiving increasing attention because of their negative impact on the quality of life and ability to perform appropriate activities. Our objective was t...

Introduction and objectives: There is an increasing interest in knowing the factors related to the wear particle-induced disease in total hip replacement (THR), after long-term follow up. Numerous studies have analyzed the development and the destruction patterns of the osteolisis. The objectives of this study were to determine the factors associated with major frequency and severity of this disease and their influence in the osteolytic progression pattern, using magnetic reso...