Bone Abstracts

Objective: The postmenopausal women and elderly men have a big burden for osteoporosis related vertebral fracture and the frequency of clinically unrecognized vertebral fracture is known to be increasing. Vertebral Fracture Assessment (VFA) using DXA is a convenient and safe method to patients together with bone density test and is reported to be proper as a screening method to prevent additional vertebral fracture as diagnosing the vertebral fracture with unrecognized symptom...

Type 2 diabetes is associated with fracture risk but, paradoxically, greater bone mineral density. The trabecular bone score (TBS) has been proposed as an index of bone microarchitecture associated with bone quality. This study compared the performance of TBS, bone mineral density (BMD), original and TBS adjusted FRAX scores in the prediction of vertebral fractures (VFs) in diabetic patients. This cross-sectional study enrolled 169 Korean postmenopausal diabetic women. Lateral...

Objectives: To prevent future osteoporosis, it is important to identify factors that affect bone health in adolescents as well as adults. This study aimed to examine the relationship between lipid profiles and insulin resistance and BMC in Korean adolescent population.Methods: Data from 706 boys and 621 girls who participated in the Korea National Health and Nutrition Examination Survey from 2008 to 2011 were analyzed. Lipid profiles were measured, and h...

Background: Aromatase inhibitors (AIs) increase the risk of fracture in patients with breast cancer. Therefore, we aimed to evaluate the long-term effects of AIs on bone health in postmenopausal women with primary breast cancer.Patients and methods: We performed a retrospective longitudinal observational study in patients with breast cancer who were treated by AIs for ≧3 years (baseline T-score >–2.5). Patients with previous anti-osteoporosis...

Objective: Due to the increase in the elderly population, osteoporosis and related fractures are increasing and causes serious social problems such as lower quality of life of seniors and economic loss. This study is aimed towards the general population in rural areas for prevalence and related risk factors of osteoporotic fracture.Materials and methods: The research comes from the Korean Rural Genomic Cohort study consisting of 10 111 people, 4090 men a...

Evidence indicates that dipeptidyl-peptidase 4 (DPP4) plays a distinct role in bone metabolism. However, there has been no report on the association, if any, between circulating DPP4 levels and osteoporosis-related phenotypes. This study aimed to determine if DPP4 predicts osteoporotic fracture (OF) risk in postmenopausal women. This case–control study was conducted in multiple centers in Korea. We enrolled 178 cases with OF and 178 age- and body mass index-matched contro...

We have reported femoral osteopenia in short term-vitamin D restricted rats without deterioration in tibial cortical bone volume (CBV), geometry or strength1. This study aimed to establish the effect of extended vitamin D deficiency in aged rat tibial volume and strength. Female Sprague-Dawley rats (9 m, n=6/group) were fed a diet containing varying vitamin D3 (D) levels (0, 2, 12, and 20 IU/day) with either low (0.1%, LCa) or high (1%, HCa) diet...

Osteoclasts are cells specialized for resorption of calcified tissue. Osteoclasts are formed from precursor cells of monocyte lineage under the control of receptor activator of nuclear factor kappaB ligand (RANKL). Mitogen- and stress-activated protein kinase 1 (MSK1) has been reported to be an important regulator of immune response and mitogenic signaling. In this study, we for the first time found that MSK1 was activated by RANKL in osteoclast precursor, bone marrow macropha...

Toll-like receptors (TLRs) appear to be involved in the pathogenesis of osteoarthritis (OA) and recent studies have suggested that polymorphisms in TLR9, an endosomal TLR are associated with knee OA in at least one population. TLR3 is also found on the surface of endosomes where they respond primarily to nucleic acid based pathogen-associated molecular patterns (PAMPs) from viruses and bacteria. We therefore determined the predictive value of TLR3 gene polymorphisms and furthe...

The aim of this study was to evaluate the adsorption of salivary proteins on giomer (Beautifil II) and composite resin (Filtek Z350).Three discs (5 mm diameter and 1 mm height) were prepared for each material. Three discs were immersed in 1 ml? of human saliva within polyethylene tube and stored at room temperature. Evaluations were performed by Bradford method and SDS gel electrophoresis for analysis of salivary protein adsorbed on giomer and composite ...