Bone Abstracts

Vitamin D deficiency in pregnancy is common, and is linked to increased risk of adverse outcomes including preterm birth, preeclampsia, infection, gestational diabetes and asthma. Vitamin D possesses well-recognized immunomodulatory functions, and programming of the immune system during foetal development can influence asthma-related risk factors and health outcomes in later life. We hypothesized that influencing vitamin D status during pregnancy would impact the immune profil...

The integration of biomaterials into the calcified bone tissue is essential for the clinical success of bone implants. A particular strategy to improve such integration is the use of specific molecules to increase osteoblast cell adhesion, proliferation, and/or differentiation on the surface of the implants, aiming to enhance the interaction of cells with biomaterials. The goal of this study was to better understand the potential of the anti-osteoporotic drug strontium ranelat...

Osteogenesis imperfecta (OI) type VI is caused by recessive null mutations in SERPINF1, encoding pigment epithelium-derived factor (PEDF), an anti-angiogenic secretory glycoprotein. Dominant mutations in IFITM5, encoding BRIL (Bone Restricted Ifitm-Like), a transmembrane protein upregulated in osteoblasts during mineralization, cause either type V OI (c.-14C>T, addition of 5 amino acids on BRIL) or atypical type VI OI (...

Aim: The aim of the research is to define the bone mineral density in patients, with Parkinson’s disease.Methods: We examined 12 women with Parkinson’s disease and 12 healthy women of appropriate age (average age: −63.6±6.25 vs 62.2±6.83 years, P=0.5). The duration of Parkinson’s disease was at list 5 years. All patients reseived levodopa.Results: BMD of women with Parkinson’s disease wa...

The first step to getting started as a post-doc is finding an appealing post-doc position. Be proactive and begin the search and application process early. One of the most critical aspects to think about is the research area. It should be something that excites you and something where you can imagine to work in for the next couple of years. Once you have decided on a research area, you can start thinking about choosing an adviser. The adviser has great power to help build a ca...

Background: Observations in rodents suggest that osteocalcin (OC) participates in glucose metabolism. Data from human studies are inconclusive and it remains unclear whether OC is simply a marker of bone turnover (BTM) or if it also mediates interactions between the skeleton and glucose homeostasis. This study determined the responses of BTMs, including OC, to oral glucose tolerance test (OGTT) in obese and normal-weight subjects.Materials and methods: P...

Strontium ranelate is a promising drug used in the treatment of osteoporosis. This drug has a unique dual effect on bone turnover, simultaneously increasing bone formation by osteoblasts (anabolic effect) and decreasing bone resorption by osteoclasts (antiresorptive effect). The goal of this study was to evaluate: i) anabolic effects of strontium ranelate on the formation of bone-like mineralized matrix in osteoblast cell cultures and ii) changes the drug could cause on the ma...

Objective: Assessment of bone mineral density in children completing therapy for lymphoma.Methods: Thirty-five children treated for childhood Hodgkin and non-Hodgkin lymphoma at the Department of Pediatric Hematology and Oncology of Medical University of Bialystok in Poland were included. Patients were scanned with DXA at two time points: 1st – up to 5 years and 2nd – above 5 years after the completion of the treatment. Bone mineral density (to...

Objective: Assessment of low bone mass in children with acute lymphoblastic leukemia.Methods: A total of 141 patients (83 boys and 57 girls) treated for acute lymphoblastic leukemia at the Department of Pediatric Hematology and Oncology of Medical University of Bialystok in Poland were assessed for low bone mineral density. Depending on age of diagnosis three clinical groups were analyzed: i) up to 5 years old, ii) from 6 to 12 years old, and iii) from 1...

Objectives: Children during the intensive treatment of cancer might be exposed to vitamin D deficiency and consequently leads to, among other things, bone deficits and low bone mass. The aim of this study was: i) to assess the serum concentration of 25-hydroxyvitamin D (25-OH-D) in children diagnosed with acute lymphoblastic leukemia (ALL) at two time points (time of diagnosis and just after induction treatment), ii) to evaluate the impact of used drugs on the changes of 25-OH...