Searchable abstracts of presentations at key conferences on calcified tissues

ba0002p9 | (1) | ICCBH2013

A 6-month intervention study with vibration therapy in severely disabled children: effects on bone, biochemical markers and acceptance

Swolin-Eide Diana , Braathen Gunnar , Emilsson Roger , Glansen Ulla , Soderpalm Ann-Charlott , Magnusson Per , Zetterlund Bosse , Westerberg Barbro , Kilebrant Sophie

Objectives: To study acceptance and the effects on bone during a 6-month whole body vibration (WBV) therapy in severely disabled children.Methods: Nineteen patients, age 5–16 years, with severe motor disabilities completed the 6-month WBV therapy standing on a self-controlled dynamic platform with vibration, jumps and rotation. The WBV was performed twice per week at 40–42 Hz. Bone mass and biochemical markers were measured at start and after 6...

ba0003pp254 | Osteoporosis: evaluation and imaging | ECTS2014

Ten-year absolute fragility fracture risk and central DXA assessment: does hypovitaminosis D matter in menopausal women?

Carsote Mara , Radoi Valentin , Dusceac Roxana , Geleriu Andreea , Mihai Alexandra , Paun Diana , Miulescu Rucsandra Danciulescu , Poiana Catalina

Introduction: The FRAX model is a new method to assess fracture risk and this aspect is important in menopause. The DXA is still the golden standard but the relationship between these two instruments is complex.Aim: We correlate the 10-year absolute fracture risk of hip (10-yH) and major fractures (10-yM) based on FRAX with or without bone mineral density (BMD) with lumbar DXA in menopause women, and we use a statistical model to find out whether the vit...

ba0006oc3 | (1) | ICCBH2017

Principal component-derived bone density phenotypes and genetic regulation of the pediatric skeleton

Mitchell Jonathan , Chesi Alessandra , McCormack Shana , Cousminer Diana , Kalkwarf Heidi , Lappe Joan , Gilsanz Vicente , Oberfield Sharon , Shepherd John , Kelly Andrea , Zemel Babette , Grant Struan

Objectives: To determine if genetic variants associated with principal component-derived areal bone mineral density (aBMD) loading scores.Methods: Our sample comprised 1,293 children of European ancestry enrolled in the longitudinal Bone Mineral Density in Childhood Study (52% female). The participants completed up to 7 annual study visits. From dual energy X-ray absorptiometry scans, sex and age-specific aBMD Z-scores were calculated for total hip, femo...

ba0007p94 | (1) | ICCBH2019

Characteristics of ultradistal radius bone density during childhood: results from the Bone Mineral Density in Childhood Study

Kindler Joseph , Mitchell Jonathan , McCormack Shana , Cousminer Diana , Chesi Alessandra , Kelly Andrea , Lappe Joan , Gilsanz Vicente , Oberfield Sharon , Shepherd John , Winer Karen , Kalkwarf Heidi , Grant Struan , Zemel Babette

Objective: The forearm is a common fracture site during childhood, but DXA pediatric reference data for areal bone mineral density (aBMD) at the ultradistal (UD) radius are lacking. The objective of this study was to first, develop age-, sex-, and ancestry-specific reference data for UD radius aBMD; second, assess the relationship between UD radius aBMD and a) other DXA aBMD measures and b) radius bone volumetric density and geometry by pQCT; and third, examine the tracking of...

ba0001pp387 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Sclerostin associated with vertebral bone marrow fat in older men but not women

Ma Vivian , Li Xiaojuan , Sigurdsson Sigurdur , Eriksdottir Gudny , Hauksdottir Alda , Palermo Lisa , Hue Trisha , Lang Thomas , Harris Tamara , Rosen Clifford , Vittinghoff Eric , Siggeirsdottir Kristin , Sigurdsson Gunnar , Oskarsdottir Diana , Gudnason Vilmundur , Schwartz Ann

Previous studies found a negative correlation between vertebral bone marrow fat (MF) and bone density (BMD). Proposed mechanisms for this include i) a shift in stem cell lineage allocation from osteoblasts towards adipocytes, and ii) an increase in osteoclast-promoting cytokines with greater MF. However, little is known about the relationship between MF and bone markers. To assess these relationships in older adults, we used data from the AGES-Reykjavik cohort. MF was measured...

ba0006p013 | (1) | ICCBH2017

Longitudinal evaluation of bone mass, geometry and metabolism in adolescent male athletes. The PRO-BONE study

Swolin-Eide Diana , Hansson Sverker , Magnusson Per , Ronne Maria , Heideman Malene , Schou Anders , Laursen Jens Ole , Wedderkopp Niels , Husby Steffen , Molgaard Christian , Ubago-Guisado Esther , Vlachopoulos Dimitris , de Moraes Augusto Cesar , Torres-Costoso Ana , Wilkinson Kelly , Metcalf Brad , Sanchez-Sanchez Javier , Gallardo Leonor , Gracia-Marco Luis Tseretopoulou Xanthippi , Amin Nadia , Mushtaq Talat , Chaplais Elodie , Naughton Geraldine , Greene David , Duclos Martine , Masurier Julie , Dutheil Frederic , Thivel David , Courteix Daniel , Ubago-Guisado Esther , Vlachopoulos Dimitris , de Moraes Augusto Cesar , Torres-Costoso Ana , Wilkinson Kelly , Metcalf Brad , Sanchez-Sanchez Javier , Gallardo Leonor , Gracia-Marco Luis Cheuk Ka-Yee , Wang Xiaofang , Yu Fiona W P , Tam Elisa M S , Ng Bobby K W , Ghasem-Zadeh Ali , Zebaze Roger , Seeman Ego , Cheng Jack C Y , Lam Tsz-Ping , Kutilek Stepan , Formanova Daniela , Senkerik Marian , Skalova Sylva , Markova Daniela , Langer Jan , Kutilek Stepan , Vracovska Martina , Pikner Richard , Fejfarkova Zlatka , Gracia-Marco Luis Vlachopoulos Dimitris , Ubago-Guisado Esther , Barker Alan R , Fatouros Ioannis G , Avlotini Alexandra , Knapp Karen K , Moreno Luis A , Williams Craig A , Vlachopoulos Dimitris , Barker Alan R , Williams Craig A , Ubago-Guisado Esther , Ortega Francisco B , Ruiz Jonathan R , Moreno Luis A , Fatouros Ioannis G , Avloniti Alexandra , Gracia-Marco Luis

Objectives: Cross-sectional studies show that exercise may have positive effects on bone outcomes in youth. However, there is no evidence from longitudinal studies, which type of sports can induce improvements in bone acquisition in adolescent athletes. Therefore, this study aimed to investigate the longitudinal differences in bone acquisition and bone metabolism between adolescent males participating in osteogenic (football) and non-osteogenic (swimming, cycling) sports compa...

ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...

ba0002p173 | (1) | ICCBH2013

Vitamin D prescription: a review of British National Formulary for children recommendations, and a proposal

Kouklinos Andreas , Lim Julian , Jacobs Benjamin

Aims: To review changes in the advice regarding vitamin D deficiency in the UK and compare these with other national guidance.Methods: All Vitamin D guidance in the Royal College of Paediatrics and Child Health 2003 guide (Medicines for Children) and in the eight editions since the British National Formulary for Children (BNFc) was first published in 2005 was reviewed.Results: Dosage and indications of prevalence are shown in the T...

ba0003s6.2 | New approaches to fracture prediction | ECTS2014

Goals of treatment for osteoporosis

Cummings Steven

Drug treatment for osteoporosis typically begins with an oral bisphosphonate, regardless of initial BMD or fracture risk and decisions to continue or change treatment are often based on evidence of ‘response’ to treatment based on changes in BMD, bone turnover markers, and occurrence of fractures. Treatment is often continued for fixed periods of time, perhaps stopped for a ‘drug holiday’.This approach differs from preventive therapy ...

ba0005p114 | Cancer and bone: basic, translational and clinical | ECTS2016

Increased zinc accumulation in mineralized osteosarcoma tissue

Rauwolf Mirjam , Pemmer Bernhard , Roschger Andreas , Turyanskaya Anna , Simon Rolf , Lang S. , Puchner S E , Windhager Reinhard , Klaushofer Klaus , Wobrauschek Peter , Hofstaetter Jochen G , Roschger Paul , Streli Christina

Abnormal tissue levels of certain trace elements such as Zinc (Zn) were reported in various types of cancer. Little is known about the role of Zn in osteosarcoma.Using confocal synchrotron radiation micro X-ray fluorescence analysis, we characterized the spatial distribution of Zn in high-grade (G3) sclerosing osteosarcoma of nine patients (4 f/5 m; 7 knee/1 humerus/1 femur) following chemotherapy and wide surgical resection. The study was done in accord...