Bone Abstracts

Objective: To compare the bone mineral density (BMD) of the lumbar spine and femur in postmenopausal women with cervical and endometrial cancer without bone metastasis with that in normal control postmenopausal women.Methods: We retrospectively analysed the BMD of the lumbar spine and femur using dual-energy X-ray absorptiometry in 130 patients with cervical cancer, 68 patients with endometrial cancer, and 225 healthy controls.Resu...

Objective: Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). There are few studies regarding the effect of diabetes on bone mineral density and hip geometry in Asian population. The aim of this study was to examine the gender-specific influence of diabetes on BMD and hip geometry.Subjects and methods: A total of 1334 subjects (571 men and 763 women) ≥50 years of age were analyzed using data fro...

Introduction: This study aims to assess 25-hydroxyvitamin D—25(OH)D—status in perimenopausal women to analyze its relationships with serum PTH levels and bone mineral density (BMD).Methods: A total of 102 individuals who visited to climacteric clinic in Sanggye paik hospital participated in the study. Serum 25(OH)D and intact parathyroid hormone (PTH) were measured. BMD was determined by dual x-ray absorptiometry (DXA) at lumbar spine, femoral ...

Introduction: The authors experienced a ipsilateral femoral stress fracture after total knee arthroplasty (TKR). Decreased bone mineral density (BMD) after TKR have been proposed as cause. However, reports regarding changes of BMD in the proximal hip after TKR have been rare. Therefore, first, we studied the question of whether TKR can effect change of proximal hip BMD? Second, if so, does TKR have different effects on BMD of the operative and non-operative sides?<p class=...

Objectives: Vitamin D dependent rickets type I (VDDR-I) is an autosomal recessive disorder with impaired activation of vitamin D, caused by mutations in CYP27B1. Characteristic clinical features are hypotonia, muscle weakness, growth failure, hypocalcemic seizures in early infancy, and radiographic findings of rickets. We aimed to describe the clinical and laboratory findings in a VDDR-1 case and to report a mutation in CYP27B1.Methods and results: The p...

The purpose of this study was to investigate the effects of fitness program with vitamin D supplementation for biochemistry related to vitamin D, muscle mass and physical functions in elderly women.The subjects were elderly women aged 65 or older, regularly visiting a senior welfare center and a senior citizen center in city. A total of 65 subjects were divided into experimental group (n=34) and control group (n=31). The intervention fo...

Sustained release of bone morphogeneic protein (BMP)-2 by heparin-contained biomaterials is advantageous for bone tissue regeneration using low dose BMP-2. However, its effect in high dose BMP-2 is still unclear and should be clarified considering the clinical use of high dose of BMP-2 in spine and oral surgery. This study aimed to evaluate the efficacy of heparin-conjugated collagen sponge (HCS) in high dose BMP-2 delivery by investigating in vivo initial osteogenic regulatio...

Study Design: Retrospective study.Purpose: To estimate the usefulness of bone scan and magnetic resonance imaging (MRI) for the diagnosis of new fracture in osteoporotic vertebral fractures.Overview of Literature: The diagnosis of new fracture in osteoporotic vertebral fractures requires simple X-ray and supplementary studies.Methods: We analyzed 87 vertebrae in 44 patients, who diagnosed with osteoporotic ve...

Introduction: The purpose of this prospective study is to investigate whether bisphosphonate-based anti-osteoporosis medication affects fracture healing and clinical outcomes of conservatively treated osteoporotic spinal fractures (OSFs).Method: A total of 105 patients who were diagnosed with acute OSFs were prospectively enrolled. According to their previous medication history, the patients were allocated into group I (n=39, no history of bisph...

Osteoclasts are cells specialized for resorption of calcified tissue. Osteoclasts are formed from precursor cells of monocyte lineage under the control of receptor activator of nuclear factor kappaB ligand (RANKL). Mitogen- and stress-activated protein kinase 1 (MSK1) has been reported to be an important regulator of immune response and mitogenic signaling. In this study, we for the first time found that MSK1 was activated by RANKL in osteoclast precursor, bone marrow macropha...