Bone Abstracts

Introduction: Hypophosphatasia (HPP) characterized by reduced mineralization occurs from mutations in the tissue non-specific alkaline phosphatase (ALPL) gene. Individuals harbouring bi-allelic mutations are generally reported to be severely affected. We report the findings of in vitro functional studies following site-directed mutagenesis in bi-allelic mutations causing extreme clinical phenotypes; severe perinatal and asymptomatic HPP.Objectiv...

Non-pharmacologic approaches to preserve or increase BMD include whole body vibration (WBV). A meta-analysis and one-year randomized trial concluded that WBV has no effect on BMD in older women; however, previous trials were relatively brief and did not include a sham control group. Therefore, we conducted the Vibration to Improve Bone in Elderly Subjects (‘VIBES’) trial, a randomized, sham-controlled trial of 10 min of daily WBV (0.3 g at 30 Hz) in seniors recruited...

Introduction: Gorham disease (GD), also known as Gorham–Stout syndrome, massive osteolysis or disappearing bone disease, is a very rare disease characterized by spontaneous and progressive osteolysis of one or more bones. Its prognosis is highly variable and unpredictable, ranging from minimal disability to death, due to involvement of vital structures, such as the vertebral column and rib cage. Osteoclasts hyperactivity has been suggested as potential pathogenetic abnorm...

Objective: We analyze changes of spine BMD and hip BMD after total knee replacement (TKR) according to osteoporosis medication, bilaterality of operation site, degree of obesity, degree of knee function and osteoporosis diagnosis at operation in female patients above 65 years old, who received TKR due to severe knee osteoarthritis,Method: 52 patients who checked 1 year follow-up BMD were enrolled. Patients were checked the spine and hip BMD at pre-operat...

Multiple myeloma (MM) is associated with lytic bone destruction leading to high fracture incidence in the vertebrae. Accurate assessment of fracture risk is required for physicians to determine the necessity for surgery. This risk is currently determined by examining lesion size or number; however, this method does not consider the biomechanical attributes of the bone. Finite element (FE) modelling can simulate mechanical loading on vertebral bodies, and estimate mechanical in...

Bone strength, hence fracture risk, is dependent on bone geometry, microstructure and bone material level properties. We have reported that microstructure and material level properties contribute independently to the increase in bone strength in rats treated with strontium ranelate for 2 years, as evaluated by μCT-based Finite Element analysis.We investigated the effects of strontium ranelate (SrRan) treatment on bone material level properties of tr...

Bone microarchitecture and material level properties independently contribute to the improvement of bone strength induced by strontium (Sr) ranelate treatment as evaluated by μCT-based finite element analysis. The influence of in vitro Sr exposure on material level properties and on bone mechanical properties is unknown.We investigated whether in vitro exposure of rat femurs to Sr is able to modify the bone mechanical properties in...

A micro-indentation technology potentially allows in vivo investigation of intrinsic bone tissue quality, a determinant of bone fragility. Thus the signification of the parameters investigated is still unclear.Since protein malnutrition affects bone material level properties – geometry and strength – rats were fed a normal or an isocaloric low-protein diet. Both femurs were collected and measurements of geometry using micro CT, materia...

Considering limited information available on skeletal system properties in foxes, the aim of this study was to determine morphological, geometrical and densitometric parameters of femur obtained from males and females. The study was performed on 1-year old male (n=5) and female (n=6) silver foxes. Right femur was isolated and its weight and length were measured. Using quantitative computed tomography (QCT) technique and Somatom Emotion Siemens apparatus, bone...

Background and aims: Vitamin D supplementation has the potential to alleviate the cardiovascular damage in diabetic patients. The present study was designed to evaluate long term impact of high doses of vitamin D on arterial properties, glucose homeostasis, adiponectin and leptin in patients with type 2 diabetes mellitus.Methods and results: In randomized, placebo-controlled study 47 diabetic patients were assigned into two groups: Group 1 received oral ...