Bone Abstracts

Multiple factors of risk have been described to the osteoporosis (OSP) and fractures in people infected by human immunodeficiency virus (HIV). Antiretroviral treatment has changed the vital prognosis of these patients, nevertheless seems that antiretroviral treatments can cause a greater loss of bone mineral density (BMD). Experts support the use of densitometry screening for HIV-infected postmenopausal women and men older than 50 years.Objectives: To ev...

Background: Oral glucocorticoids (GC; prednisolone dose of 0.75 mg/kg per day), help to preserve muscle strength and prolong independent walking in boys with DMD. This study compared longitudinal growth, body mass index (BMI), bone mineral density (BMD), vertebral fractures (VFs) and ambulatory status in boys with DMD on daily (DAILY) or intermittent (INTER; 10 days on & 10 days off), oral GC regimens.Methods: 50 DMD boys from two UK centres were inc...

Objectives: Weight loss therapy is the principal non-pharmacological method for prevention and treatment of simple obesity in childhood. This intervention may influence bone metabolism in children, but this phenomenon is not well understood. The aim of this study was to assess the changes in body composition and in the profile of bone markers after weight loss in obese prepubertal children.Methods: We determined serum BALP (bone alkaline phosphatase), CT...

Objectives: i) To evaluate the bone mineral density (BMD), and clinical outcomes of intravenous bisphosphonate treatment (IVT) and after treatment discontinuation in children with osteogenesis imperfecta (OI). ii) To compare the clinical outcome of those who discontinued IVT and those who had progressed from IVT to maintenance oral bisphosphonate therapy.Methods: A retrospective study was conducted on 28 children with OI who had discontinued IVT (21 pami...

In children with spinal muscular atrophy (SMA): i) describe bone mineral density (BMD) measured by dual-energy x-ray absorptiometry (DXA); ii) examine bone health factors; iii) examine change in BMD over time and pamidronate effect.DXA results, medications, ambulation, 25-OH-Vit D levels, and fracture history were retrospectively reviewed in 14 children (five girls) with SMA. Sites scanned included whole body (WB), lumbar spine (LS), and lateral distal f...

Objectives: Cyclical intravenous pamidronate (PAM) and zoledronic acid (ZOL) increases bone mineral density (BMD) and reduces fractures in children with osteogenesis imperfecta (OI). The aims of this study were to evaluate fracture and BMD outcomes after treatment discontinuation in children with OI treated with ZOL compared to PAM.Methods: 21 patients (mean age 5.1±3.8 years) received PAM (1 mg/kg per day x 3 days q 3 months for the first year). Se...

Objectives: To evaluate vitamin D and bone mineral density (BMD) status in children with Duchene muscular dystrophy (DMD) in relation to fractures and ambulation status using gross motor scale function classification system (GMFCS).Methods: Clinical data of 53 DMD patients (mean age 12.1 years, range 4.9–19.6) at the first visit to the Endocrine/Bone Clinic at Nationwide Children’s Hospital were retrospectively studied. The patients were strati...

Objective: To study any possible relations of vitamin D status and metabolic syndrome (MetS) components in children, since there is evidence for extraskeletal functions of vitamin D, and its deficiency may contribute to the pathogenesis of several major diseases. In addition to explore any possible role of birth weight (BW).Methods: Clinically healthy children aged 3–9 years (n=152) were included in the study. Forty-six were born large for ...

Thalassemia (Thal) is a genetic disorder of hemoglobin synthesis. In its most severe form patients require chronic blood transfusions to sustain life leading to iron overload unless excess iron is removed by chelators. Deferasirox (DFX) and deferoxamine (DFO) are the two most common chelators. DFX has recently been shown to reduce osteoclast activity in vitro.Objective: To explore the association between chelation therapy, bone density and verte...

The link between scoliotic deformity and bone metabolism in adolescent idiopathic scoliosis (AIS) has not been well researched. Moreover, the data concerning the cross-talk between leptin level and bone markers in this group of patients are lacking. The objective of this study was to correlate the extent of scoliotic-curve severity with the bone turnover and leptin level in girls with AIS. The study encompassed 77 AIS girls, aged 14.7±2.17 years. Scoliotic curve severity ...