Bone Abstracts

Titanium (Ti) surface with nanotopography induces osteoblast differentiation, at least in part, by upregulating the expression of α1/β1 integrins. Thus, we hypothesized that other potential candidates from the integrin signalling pathway may be involved in the osteogenic potential of nanotopography. In this context, the aim of this study was to compare the expression of integrin family members of cells grown on nanotopography with machined surface. Machined Ti discs ...

Context: As bone metabolic markers, recent studies indicated vitamin D and osteocalcin (OC) were also involved in energy metabolism. While the exact relationship between vitamin D and OC in regulating energy metabolism is unclear. One of the possibilities is that: low vitamin D could lead to secondary hyperparathyroidism and following high bone turnover, which would enhance the quantity of bioactive OC.Objective: Our aim was to study whether OC mediated ...

Objective: To assess the effect of mechanical loading in anorexia nervosa (AN) in vivo, by comparing bone geometry and microarchitecture in weight bearing versus non-weight bearing bone.Subjects and methods: A total of 26 female patients with AN, and 26 female controls matched on age and height were included. Bone geometry, volumetric bone mineral density (vBMD) and microarchitecture were assessed using HR-pQCT (Scanco Medical, Brütisellen,...

Introduction: Hip fracture is a significant health problem with 25–30% occurring in men. Outcome differences between the genders have been documented, particularly mortality rates.Aim: To prospectively investigate outcomes of elderly hip fracture patients regarding mortality, recovery of function, quality of life, incidence of osteoporosis, osteoporosis knowledge, medication adherence, nutritional status and fear of falling.Me...

Lactation in both humans and mice is associated with a substantial bone loss, in mice this bone loss is recovered within 4 weeks after weaning. This recovery is considered to be the most rapid physiological bone formation in adult life. The aim of the study was to investigate the effect of the post-lactational anabolic response on a disuse bone loss induced by Botulinum toxin (BTX).Forty-eight NMRI mice were divided into the following groups: pregnan...

Objective: Multiple endocrine neoplasia type 1-related PHPT (MHPT) differs in many aspects from sporadic PHPT (SHPT). The aims of the study were to summarize the clinical features of Chinese MHPT and compare the severity of the disease with SHPT.Design and methods: A total of 40 MHPT cases (27 sporadic, seven families) and 169 SHPT patients of Chinese descent were retrospectively analyzed. X-rays and ultrasound were used to assess the bone and urinary sy...

Objectives: ADO2 is a genetic bone disease induced by dominant negative mutations of the proton/chloride antiporter ClC7 encoded by the CLCN7 gene. In osteoclasts, ClC7 is crucial for lysosome function and resorption lacuna acidification. However, Clcn7 is expressed in several cell types in various organs, including brain, lungs, kidneys and spleen. Therefore, we asked whether Clcn7 mutations could affect other tissues beyond the bone.<p class="a...

Backgound: Limited data are available on body composition of preterm compared to born at term infants. The aim of our study was to compare bone mass, fat mass-FM and free fat mass-FFM in preterm and term infants at 40th weeks of gestational age (GA).Methods: Thirty-four preterm infants (14M, 20F) born at 31.0±2.2 weeks of GA (range 26–36+3 weeks) and n=8 term neonates (4M, 4F) born at 39.7±1.0 weeks of GA underwent a to...

Exercise can prevent or mitigate musculoskeletal challenges of aging. To prescribe an effective /osteogenic exercise program the individual’s muscle strength, bone mineral density, and cardiovascular status would need to be considered.Osteoporotic vertebral fractures and resulting mal-posture create musculoskeletal challenges that cannot be met with pharmacotherapy alone. Bone loss, disequilibrium along with pain can increase inactivity, and further...

Objective: To study the trends in prescription of different anti-osteoporotic drugs (AOD) in the UK population aged 50 years or above from 1990 till 2012.Methods: Retrospective observational study using the CPRD data link representative for the total UK population. The incidence of prescription of a specific AOD was calculated by dividing the number of prescriptions by the total person-years (py) of follow-up.Results: AOD prescript...