Bone Abstracts

Objective: In children, factors such as age and puberty are confounders when investigating associations of fat or lean with bone mineral content (BMC). Our aim was to assess influence of fat on BMC in overweight/obese (ow/ob) and normal weight (nw) children at different stages of puberty.Methods: Cross-sectionally, 244 children+adolescents (6–16 years) (73nw, 177ow/ob) were assessed (tanner staging (TS), body composition (DXA) (total body BMC, lean ...

Background: Cannabinoid receptors are expressed in synovial joints but their role in joint disease is unknown. Here we examined the role of the type 2 cannabinoid receptor (CB2) in the pathogenesis of age-related osteoarthritis and osteoarthritis caused by destabilisation of the medial meniscus (DMM) in WT and CB2-deficient mice (Cnr2−/− mice).Methods: The severity of arthritis was graded histologically according to standard techni...

Bone resorption and formation occur in a tightly regulated fashion reflecting the coupled activities of osteoclasts and osteoblasts. Several pathological conditions perturb this balance, including osteoporosis and skeletal metastases. In the case of metastases, the uncoupling of resorption and formation activities contributes to disseminated tumor cells homing to the bone and to tumor growth within the bone in highly localized regions. Therefore, a site-specific marker of bone...

Purpose: To determine the association between socio-economic status (SES) and risk of hip fracture.Methods: Retrospective cohort study. We used a population database which contains primary care and hospital inpatient records of over >5 million people. Anyone registered in this database in 2009–2012 and resident in an urban area was eligible. Main measures: a validated SES composite index (accounting for proportion of unemployed, insufficiently e...

see P221b....

Introduction: Runt-related transcription factor 2 (RUNX2) is a major transcription factor essential for the regulation of osteoblast and chondrocyte differentiation, hence affecting skeletogenesis, bone and cartilage formation. The RUNX2 protein has unique consecutive polyglutamine and polyalanine repeats (Q/A) which are important for its transactivation function. Several variants within the RUNX2 gene have been implicated in osteoporosis and fracture susceptibility.<...

Purpose: Systemic sclerosis (SSc) is a rare inflammatory rheumatic disease that has been associated with an increased risk of low bone mineral density (BMD). However, data on risk factors associated with bone loss in SSc are scarce. The objective of this study was to investigate the prevalence of and the risk factors for low BMD in patients with SSc.Methods: Cross-sectional data of 61 patients with SSc were collected. BMD in the lumbar spine, total hip a...

Introduction: Osteogenesis imperfecta is a rare constitutional bone disease. The bone matrix is poor because of the often mutation on the gene coding for collagen I, leading to many fractures. Classification Sillence completed by Glorieux, describes the clinical variability. The management should be done case by case.Study objective: Evaluate the clinical profile, biological and radiological of 5 newly diagnosed cases.Material and ...

Background: Atypical Femur Fracture (AFF) has become widely reported as a complication of bisphosphonate therapy in adults since the first case report in 2005. A trend towards a similar pattern of fractures has been reported in children in Sheffield in 2012. A 13 year old boy was reported in 2014 with an ‘AFF’ of the tibia but that fracture did not meet the standard diagnostic criteria of AFF. Last year a 16-year-old girl treated with pamidronate for idiopathic juven...

Background: Mutations in the ENPP1 gene have been identified in individuals with generalized arterial calcification of infancy (GACI), a life-threatening disorder characterized by calcification in the blood vessels, because of reduced availability of pyrophosphate. We describe a case of GACI due to a novel ENPP1 mutation.Presenting problem: The patient, born at term to non-consanguineous parents, was referred to us at birth with weak femoral pulses for e...