Bone Abstracts

Introduction: Indirect inhibition of the extracellular BMP antagonist network and the activation of Wnt signaling by PTH1-34 suggest the possibility of synergistic effect on bone regeneration by the co-administration of BMP and PTH1-34.Materials and methods: In a rat critical-sized femoral defect (7 mm) model, SD rats (n=32) were operated by absorbable collagen sponge containing two different BMP-2 dosage treatments; 1) 2 μg (low dose) and ...

Adiponectin has recently been shown to influence skeletal metabolism. Over-expression of adiponectin gene suppresses bone resorption and increases trabecular bone mass. Bone marrow stromal cells from adiponectin-null mice had reduced mineralized nodule formation ability compared with wild type mice. Adiponectin, signalling via the adiponectin receptor 1 (AdipoR1) stimulates osteoblast differentiation and inhibits osteoclastogenesis. We have shown that the globular for...

The aim of the study was to evaluate the peculiarities of body composition in postmenopausal women depending on bone mineral density (BMD).Materials and methods: We’ve examined 8882 women aged 20–89 years (mean age – 56.7±0.14 years; mean height – 162.5±0.07 cm; mean weight – 73.5±0.16 kg). Anthropometric measures were performed in 80 postmenopausal women aged 40–82 years (mean age – 63.53±1.08 years...

Bone-marrow mesenchymal stem cells (MSCs) are the origin of bone-forming cells with immunomodulation potential. Among the generated immunosuppressive molecules there is HLA-G5. HLA-G proteins play a crucial role in promoting the acceptance of allografts. However, the mechanisms regulating the expression of HLA-G5 in human MSCs are unknown. We induced differentiation of human MSCs (harvested from iliac crests of healthy volunteers after their informed consent following approved...

Tannerella forsythia is a gram-negative, anaerobic, asaccharolytic, fusiform bacterium. The presence of the bacterium is associated with various forms of periodontal disease, including gingivitis, chronic and aggressive periodontitis. The expression of GroEL, a bacterial heat shock protein, increases in stressful conditions such as infection. GroEL is a moonlighting protein that has multiple functions. The aim of this study was to evaluate the effect of T. forsyth...

Objectives: Murine studies have shown that iron deficiency during pregnancy can cause abnormal phosphate and bone metabolism in offspring by elevating concentrations of fibroblast growth factor-23 (FGF23). FGF23 exists in plasma as an intact phosphate- and vitamin D-regulating hormone and its C-terminal fragment, a cleavage product that possibly antagonises the intact hormone. These findings are pertinent to low-income countries, where the prevalence of iron deficiency in preg...

Objectives: To have a better understanding of the applicability of the Greulich and Pyle and Tanner Whitehouse methods of bone age estimation in children who are of a different ethnicity from those of the original standards.Method: A systematic search of the Medline database was conducted to include studies published between 1st January 1959 and 1st May 2016 (keywords ‘Greulich Pyle’; ‘Greulich and Pyle’) and 1st January 2001 and 1st ...

Objectives: Patients with anorexia nervosa (AN) are at high risk of reduced bone mass. The aim of this intervention study was to investigate the long-term effects on bone and body composition three years after intense weight gain therapy.Methods: Twenty-five female AN patients, mean age 20.1 years, mean BMI of 15.5 kg/m2, were included. Twenty-two patients fulfilled the treatment for 12 weeks with a high-energy diet. Body composition and bone ...

Bone morphogenetic protein 6 (BMP6) is a member of TGF-β superfamily with a high potential to induce new bone and cartilage. Here we demonstrate that BMP6 compared to the BMP7 paralog has unique biological properties. Previously, we showed that BMP6 is more active at lower amounts then BMP7 because of increased resistance to noggin due to lysine in position 60. Next, we discovered that BMP6 binds to blood coagulum components, which when modified with calcium salt and a fi...

Introduction: The body composition at term equivalent age of infants born preterm is different than that of infants born at term.Aim: The aim of the study was to compare the body composition in preterm and full-term infants at age 3 and 4 years.Patients and methods: Total body bone mineral content (TBBMC, g), density (TBBMD, g/cm2), and body composition (fat mass – FM, g; lean body mass – LBM, g) were measured ...