Bone Abstracts

Backgrounds: Ossification of the posterior longitudinal ligament (OPLL) is characterized by pathological ectopic ossification of the posterior longitudinal ligament. Development of OPLL induces compression myelopathy or radiculopathy by spinal stenosis and the loss of spinal flexibility by ankylosing spinal hyperosteosis (ASH). Although the etiology of OPLL has not been fully elucidated, systemic and local bone formation factors may play a role in the pathogenesis of OPLL. The...

Objectives: To establish the average bone mineral density (BMD) and bone mineral content (BMC) in young male population from the different ethno-geographical groupsMaterials and methods: Estimations of the calcaneal BMD (g/cm2) and BMC (r), using on ALOKA-5.0 DXA machine among Indian (n=58) and Nigerian (n=72) male students (17–20 years), were done. The anthropometric program included body weight, height, shoulder and th...

Objectives: The ketogenic diet (KD) is a medically supervised, high fat, low carbohydrate and restricted protein diet which has been used successfully in patients with refractory epilepsy. Only one published report has explored its effect on the skeleton. We postulated that KD impairs bone mass accrual and examined skeletal health parameters in this patient group.Methods: Patients commenced on the KD from 2002–2009 were enrolled in a prospective, lo...

Introduction: Osteopenia is a well-known complication of anorexia nervosa (AN) in older adolescents and adults, especially in those with a long duration of the disease and a severe underweight.Aim: We investigated whether young premenarchal girls with AN have similar risk factors for a disturbed bone growth and mineralization.Methods: Twenty-four female premenarchal AN patients as well as 24 age and height matched female controls u...

The aim of the study was to evaluate relationships between morphometric, densitometric and mechanical properties of tarsometatarsus in ostriches (Struthio camelus). Males (n=9) and females (n=15) were kept to slaughter age of 14 months of life to obtain left tarsometatarsus. Using computed tomography technique (Somatom Emotion, Siemens), volumetric bone mineral density (vBMD) of the trabecular (Td) and cortical bone (Cd) were measured. Areal BMD and ...

Limb length discrepancy has been observed in children with hemiplegic cerebral palsy (HCP). However, the difference of bone age and limb lengths have been a controversial issue. The purpose of this study was to analyze the bone age and the upper extremity segmental lengths between affected and naffected in HCP patients.Seventy-eight patients (39 boys and 39 girls; mean age 71.3±28.1 months). Fourty-five children were right and 33 were left hemiplegi...

The analysis of intact parathyroid hormone (PTH) (PTH1–84) is useful in the diagnosis of hyper- and hypocalcaemia, hyperparathyroidism, and in the prevention of bone mineral disorders in renal patients. However, the analysis is complicated by the presence of PTH fragments. These are especially prone to accumulation in renal failure, and cross-react differently with different immunoassays, including the most recent, third-generation immunoassays. As such, large variability...

1,25-Dihydroxyvitamin D (1,25D) is one of the major regulators of calcium metabolism. Due to its lipophilic nature and low circulating concentration, the measurement of 1,25D concentration levels has been labour intensive and technique dependent in addition to multiple equipments required for the sample purification procedure. We reported the results of soon to be commercialised fully on-board IDS-iSYS 1,25 VitDXp assay.IDS-iSYS 1,25 VitD...

Objective: Currently, majority of the osteoporotic patients are not diagnosed i) a new ultrasound based device (Bindex) has been recently introduced for osteoporosis (OP) screening and diagnostics at primary healthcare ii) Bindex measures cortical thickness and determines parameter called density index (DI). Thresholds for DI in OP assessment have been determined in Finnish-Caucasian (F-C) population (n=448) along the International Society of Clinical Densitometry (IS...

The selective cathepsin K inhibitor odanacatib (ODN) is currently in development for the treatment of postmenopausal osteoporosis. Our goal was to evaluate the effects of ODN vs alendronate (ALN) on bone mass and strength of lumbar vertebrae (LV) in orchiectomized (ORX) rabbits, a model of male osteoporosis. Adult male rabbits (11 months old) were subjected to sham- (n=20) or ORX-surgery (n=24/group) for 7.5 months before dosing initiated. ORX animals were ra...