Bone Abstracts

Spinal cord injury (SCI) has been associated with a marked increase in bone loss. This study analysed the effect of Wnt signalling antagonists (sclerostin and DKK-1) and their relationship with bone turnover markers and BMD evolution in patients with a recent SCI.Methods: Patients with a recent complete motor SCI (AIS A or B); (<6 months) were prospectively included. Bone turnover markers (bone formation: P1NP, bone AP; bone resorption: sCTx), Wnt an...

Objective: The incidence of eating disorders has increased in 15–19 years old1. There is growing concern as to its impact on bone health during adolescence where peak bone mass acquisition is of paramount importance. This paper describes bone size and size adjusted bone mineral content in an adolescent/young adult eating disorder population.Methods: A total of 68 patients (63 F/5 M, 90% anorexia nervosa and 10% atypical eating disorder), ...

Children bone knowledge is relatively sparse. This is especially true for infant and for bone microarchitecture data. We have investigated, in this study, the age-related modifications of spine microarchitectural texture, as assessed by TBS, on male and female infants during their two first years of life.The study group was composed of 143 and 109 healthy female and male infants aged between 0 and 2 years. Height and weight Z-scores were signifi...

Low protein diet (LPD) impairs body growth, decreases serum IGF1 and increases serum FGF21, two hepatokines influencing bone growth. Low calcium-phosphate diet (LCaPiD) increases serum calcitriol. We hypothesized that LPD effects on bone growth may differ according to calcium and phosphate intakes through the hormonal modulation of calcitriol, IGF1 and FGF21. One-month old rats were fed isocaloric diets containing 10 or 5% casein (10Prot, 5Prot), with 1.0% calcium and 0.8% pho...

Background: Patients with differentiated thyroid cancer (DTC) are treated with L-thyroxine (L-T4) in relatively hight doses to suppress endogenous TSH levels. Very long-term effect of thyroid hormones supplementation on bone are controversial.Objetive: To study the possible negative effects on bone mineral density (BMD) and bone markers in DTC patients followed in our center.Methods: A 46 po...

BMD alone is not sufficient to predict the fracture risk for an individual. Others parameters, such as microarchitecture play a key role in bone fragility. Several cross-sectional studies have shown the ability of TBS to discriminate fractured from healthy subjects in European populations. The aim of our study is to assess the ability of TBS, evaluated at the lumbar spine, to discriminate subjects with and without fracture in a large white US population....

Background: Resveratrol (RSV) is a natural polyphenolic compound, found in fx grapes, which possesses anti-inflammatory properties. RSV inhibits osteoclast activity and promotes osteoblastogenesis in vitro. Furthermore, RSV protects against bone loss after ovarectomy and immobilization in animal models. RSV treatment of obese men for 4 weeks resulted in an increase in bone specific alkaline phosphatase (BAP).Hypothesis: Low-grade inflammation is...

Background: Crohn’s disease (CD) is an inflammatory bowel disease which affects many organ systems including the skeleton. In children with CD, bone mineral density is frequently low. Bone metabolic abnormalities, including lower biochemical measures of bone turnover (NTX) as well as decreased bone formation indices at the tissue level have been reported. The aim of our study was to gain information on the bone matrix mineralization in CD.Methods: W...

Objectives: Within the National Health Service there is a recognised need for supporting young peoples transition into adult services1. Focus groups and forums have historically been used to identify how to achieve ‘good’ transition between services, from the perspective of patients, carers and professionals. A recent article recommended an individualised programme supporting transition for young people with osteogenesis imperfecta (OI)2. The ai...

Objectives: To assess the effects of short-term vitamin D supplementation on bone metabolism, glycaemic status and immune function in vitamin D deficient children.Method: Treatment with daily 5000 IU cholecalciferol supplementation for 6 weeks. At baseline and end of treatment serum 25 hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), alkaline phosphatase (ALP), serum collagen type 1 cross-linked C-telopeptide (CTX), serum calcium, HbA1c, sex hormon...