Bone Abstracts

Background: Although both testosterone and estrogens are considered essential for normal bone growth, epiphyseal maturation and bone mass accrual during adolescence, only very few data concerning the changes of estrogens, bone maturation, bone mineral density (BMD) and bone geometry in healthy boys at different pubertal stages have been published.Objectives: This study aimed to analyze the relationship between sex steroids and more especially estrogens a...

Over the years, it has been demonstrated that the ability to maintain body core temperature in older adult’s declines with age. Temperature is a vital physical factor for cell growth and a downshift in core body temperature (<37 °C) might have a direct affect on maintaining bone density or repair fractures. Disruption in any of the cellular processes involved in bone remodelling leads to a net loss of bone mineral density and bone loss. Therefore our study looked...

It is unclear as to whether western dwelling South Asian (SA) postmenopausal women have a different fracture risk to that of the native Caucasian (C) population. Moreover, the WHO Fracture Risk Assessment Tool (FRAX) has not been used previously to compare predicted risk of fractures in western dwelling South Asian women with same-age Caucasian women. This analysis used data from n=35 SA [mean (S.D.) age=59 (6) years] and n=136 C [mean (...

Introduction: The FRAX tool can be used to assess absolute fracture risk, but the majority of treatment decisions are still based on measurements by DEXA. In remote rural Greek areas, after the socioeconomy crisis, access to the nearest DEXA facility became more difficult.Purpose: Role of combined QUS and FRAX in the identification of low risk patients who do not require DEXA applying a FRAX threshold of 4% for the 10-year major osteoporotic fracture pro...

Existence of inflammatory osteoclasts (iOCLs) contributing to pathological bone resorption associated with inflammatory diseases has been suspected for many years. However, specific markers of iOCLs are lacking, making impossible to establish the contribution of iOCLs to such pathologies. Whereas in steady state OCLs derive from monocytes (MN-OCLs), in inflammatory conditions, they also differentiate from dendritic cells (DC-OCLs). We recently showed that these 2 OCL populatio...

Objective: Due to the increase in the elderly population, osteoporosis and related fractures are increasing and causes serious social problems such as lower quality of life of seniors and economic loss. This study is aimed towards the general population in rural areas for prevalence and related risk factors of osteoporotic fracture.Materials and methods: The research comes from the Korean Rural Genomic Cohort study consisting of 10 111 people, 4090 men a...

Alendronate is one of the most popular anti-resorptive drugs and widely used to treat osteoporotic patients in the world. In Japan, alendronate oral jelly (ALN-J) as a new formulation was launched in 2013. Dissolution test and bioequivalence study were performed between ALN-J and alendronate oral weekly tablet (ALN-T), and bioequivalence of both drugs was approved. Dosage and administration of ALN-J is the same as ALN-T. Moreover, ALN-J has special features of easy swallowing ...

Introduction: Osteocalcin (OC) is the noncollagenous protein of bone matrix produced by osteoblasts which play an important role in bone metabolism. In its carboxylated form (c-OC) osteocalcin binds to hydroxyapatite in bone and plays a regulatory role in bone formation and mineralization. In contrast, undercarboxylated OC (uc-OC) binds less effectively to hydroxyapatite and a significant association has been found between fracture incidence and uc-OC in elderly subjects. Unde...

Objectives: Respiratory and Ear, Nose and Throat (ENT) complications are commonly reported in children with achondroplasia but little data is available regarding prevalence and outcome. In an unselected cohort of children with achondroplasia, we studied the prevalence of:•Abnormal cardiorespiratory sleep studies•Speech and hearing impairment</ce:p...

Osteoclasts are cells specialized for resorption of calcified tissue. Osteoclasts are formed from precursor cells of monocyte lineage under the control of receptor activator of nuclear factor kappaB ligand (RANKL). Mitogen- and stress-activated protein kinase 1 (MSK1) has been reported to be an important regulator of immune response and mitogenic signaling. In this study, we for the first time found that MSK1 was activated by RANKL in osteoclast precursor, bone marrow macropha...