Bone Abstracts

Non-pharmacologic approaches to preserve or increase BMD include whole body vibration (WBV). A meta-analysis and one-year randomized trial concluded that WBV has no effect on BMD in older women; however, previous trials were relatively brief and did not include a sham control group. Therefore, we conducted the Vibration to Improve Bone in Elderly Subjects (‘VIBES’) trial, a randomized, sham-controlled trial of 10 min of daily WBV (0.3 g at 30 Hz) in seniors recruited...

Introduction: Pregnancy- and lactation-associated osteoporosis (PLO) is an uncommon disease. The majority of cases are seen in the third trimester or early post-partum in the primagravid women and the prominent clinical feature of PLO is the severe and prolonged back pain and height loss. To date the prevalence and the aetiology of this disorder are unclear and there are no guidelines for its treatment.Case report: We report the outcomes of teri...

Hypophosphatasia is a recessively inherited disorder with a wide phenotypic manifestation ranging from lethality in neonates to asymptomatic in adults. The severity of the phenotype is largely determined by the nature of the ALPL mutations. We describe a previously asymptomatic adult whose phenotype dramatically changed after he developed renal failure. A 50-year-old man was diagnosed with IgA nephropathy. At age 52 (eGFR 50 ml/min) he suffered his first metatarsal fr...

Objectives: To describe the response to treatment with teriparatide for osteoporosis associated with Hajdu–Cheney syndrome after a follow-up 2 years.Material and methods: A 51-year-old woman presented in our outpatient clinic with pseudo-clubbing of some fingers and toes. She was short (139 cm) and thin (34 kg). She also had some facial and cranial abnormalities: thin lips, long philtrum, full cheeks, micrognathia, short neck, bushy eyebrows and coa...

Synthetic glucocorticoids such as dexamethasone (Dex) are widely used for treatment of premature infants with chronic lung disease or respiratory distress syndrome or in allergic conditions such as asthma. Adverse effect of these treatments is glucocorticoids-induced osteoporosis. On the other hand there are functional foods, for instance 2-oxoglutaric acid (2-Ox) a precursor of hydroxyproline the prevailing amino acid in bone collagen, which reduce the risk of osteoporosis. T...

Introduction: Low-magnitude, high-frequency (LMHF) mechanical stimuli lead to enhance bone formation and decrease resorption. This study aimed to investigate the effect of vibration on the bone loss induced by inflammatory cytokine, lipopolysaccharide (LPS).Methods and designs: Balb-C mice were administered to LPS (5 mg/kg) with two i.p. injections on days 0 and 4, while sham control group was injected with 400 μl of water for injection without LPS....

Adaptive responses of the skeleton to loading changes architecture and physical properties in order to optimise strength for function. However, bone is subjected to many local and circulating osteotropic factors, most acting on G-protein coupled receptors. Receptor activity modifying protein-3 is a single trans-membrane domain receptor accessory protein, which aids in trafficking of calcitonin and calcitonin-like receptors to the cell surface and changes ligand selectivity. As...

The P2Y2 receptor is a G-protein-coupled receptor and the natural ligands (ATP/UTP) strongly inhibit mineralized bone nodule formation by osteoblasts in vitro. We have earlier shown that overexpression of the P2Y2 receptor in vivo resulted in decreased bone mineral density (BMD), partially due to increased bone resorption, but also decreased formation (detected by serum bone markers and bone histomorphometry).This ...

Low protein or low calcium intake are known to impair bone growth, but their combined effects on determinants of bone strength are not well understood. We investigated the influence of various protein and calcium containing diets on determinants of bone strength in growing rats.One-month-old female rats were fed isocaloric diets containing 10, 7.5 or 5% casein, with 1.1% (normal; NCa) or 0.2% calcium (low; LCa) during 8 weeks. Tibia midshaft geometry (ou...

There is a growing body of evidence indicating the important role of the neonatal steroid milieu in programming sexually dimorphic pattern in various physiological systems. We tested the hypothesis that abnormal exposure to steroid hormones within a critical developmental period elicits permanent changes on tooth eruption, enamel mineralization, and leptin and corticosterone concentrations in adulthood. Newborn Wistar rats were divided into four groups, two male groups and two...