Bone Abstracts

Objectives: Children who fracture have lower bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) than children who do not sustain fractures, but there is little data on bone microarchitecture in relation to childhood fracture. We assessed tibia microarchitecture using high resolution peripheral quantitative computed tomography (HR-pQCT) in children with recent fracture and those without a history of fracture.Methods: Children ag...

The aim of the study was to evaluate the peculiarities of body composition in postmenopausal women depending on bone mineral density (BMD).Materials and methods: We’ve examined 8882 women aged 20–89 years (mean age – 56.7±0.14 years; mean height – 162.5±0.07 cm; mean weight – 73.5±0.16 kg). Anthropometric measures were performed in 80 postmenopausal women aged 40–82 years (mean age – 63.53±1.08 years...

Biographical DetailsDr Frank Rauch obtained his MD degree from the Technical University of Munich, Germany, and trained as a pediatrician at the Children’s Hospital of Cologne University, Germany. Since 2001 Dr F Rauch has been a clinician-scientist at the Shriners Hospital for Children and is currently a Professor of Pediatrics at McGill University, Montreal, Canada. His clinical an...

Objective: We have observed sex-specific effects of pregnancy calcium carbonate supplementation in 8–12 year old Gambian children, indicating slower growth after infancy in girls born to calcium-supplemented mothers but faster in boys.1,2 IGF-1 is a key driver of growth and is responsive to calcium supplementation.3 The aim of this study was to determine whether the pregnancy supplement had resulted in sex-specific effects on mid-childhood IGF1 of th...

Bone is a tough composite material, comprised of a compliant collageneous matrix, brittle apatite mineral crystals and a suite of non-collageneous proteins (NCPs). Bone material properties depend on these components, and their interactions at the mineral-collagen interface. ‘Bone mineral density’ (BMD), a parameter used to predict fracture risk, is routinely quantified by DEXA. Previous studies used ex vivo emu tibiae as a model to test the effect of organic...

Objectives: To describe the incidence of vertebral fractures in steroid-treated children.Methods: Fractures were assessed prospectively each year for 3 years according to the Genant semi-quantitative method. Proportions of children with incident fractures were determined annually over the study period. To examine associations with baseline clinical factors, the 3-year total number of incident fractures was analyzed using multivariable Poisson regression....

The aim of our study was to evaluate the anthropometric characteristics in postmenopausal women depending on appendicular skeletal mass.Materials and methods: We’ve examined 8882 women aged 20–89 years (mean age – 56.7±0.14 years; mean height – 162.5±0.07 cm; mean weight – 73.5±0.16 kg), among them anthropometric measures were performed in 79 postmenopausal women aged 40–82 years (mean age – 63.53±1....

Aim of research: To determine the prevalence of hyperuricemia affecting the Ukrainian men in relation to the bone mineral density and TBS.Object of research: The Ukrainian men (n=132), age of the examined patients –from 50 to 80 years. Average age of examined patients was 58.2±1.3 years. According to the levels of uric acid in the blood serum, all patients were divided in four quartiles.Methods of research: Uric ...

Today, there are more than 450 well-characterized genetic skeletal disorders classified primarily on the basis of clinical, radiographic, and molecular criteria. Although individually rare, the overall birth incidence is estimated to be 1/5000 live births. Half a century ago, in the 1960s, individuals with disproportionate short stature were diagnosed either with achondroplasia (short-limbed dwarfism) or Morquio syndrome (short-trunked dwarfism). In time, delineation of numero...

Objectives: Cross-sectional studies show that exercise may have positive effects on bone outcomes in youth. However, there is no evidence from longitudinal studies, which type of sports can induce improvements in bone acquisition in adolescent athletes. Therefore, this study aimed to investigate the longitudinal differences in bone acquisition and bone metabolism between adolescent males participating in osteogenic (football) and non-osteogenic (swimming, cycling) sports compa...