Bone Abstracts

Objective: Osteogenesis imperfecta (OI) which is a heterogenic group of diseases presenting with bone fragility, skeletal deformations and limited mobility may confer a risk of several non-skeletal health issues and is associated with adaptational social problems. The aim of the qualitative descriptive study was to determine the most important areas (problems?) related to social functioning, familial environment, hospital amenities and social needs in children with OI.<p c...

Objectives: Limited data exist on growth parameters in children with hypophosphatasia (HPP), a rare metabolic disease characterized by impaired bone mineralization. We aimed to describe growth characteristics in untreated children with HPP enrolled in the Global HPP Patient Registry.Methods: Children (<18 years old) with a diagnosis of HPP who were not receiving enzyme replacement therapy with asfotase alfa at the time of evaluation were identified f...

Objectives: Chronic non-bacterial osteomyelitis (CNO) is a heterogenic group of immune-mediated inflammatory bone diseases with unclear pathogenesis. Only a few genes associated with this condition have identified. The aim of the study was to evaluate the spectrum of mutations in genes associated with primary immunodeficiency syndromes (PIDs) and autoinflammatory diseases (AIDs) in the cohort of patients with early-onset CNO from North Caucasus (Dagestan and Chechnya) and asse...

Objectives: From late 2015 a new protocol for zoledronic acid was adopted in our centre. This led to many children changing from pamidronate (PAM) to zoledronic acid (ZA) treatment. In a minority of cases the children and/or their families felt strongly that they wanted to change back to PAM. We present the characteristics of that minority and how bone turnover markers (BTMs) and bone mineral densities (BMD) changed whilst on ZA.Method: From Nov 2016 to ...

Objectives: Association of grip strength (GS) with anthropometric parameters has been reported. Our objective was to assess grip strength in 6 to 18-year-old healthy Indian children (urban and rural) and study the association of GS with body composition.Methods: This was a part of a multicenter, cross-sectional, observational school-based study; multi-stage stratified random sampling was carried out and children (n=1980) from various urban (...

Objectives: Adolescents with Developmental Coordination Disorder (DCD) have significantly lower bone mineral density (BMD) compared to their non-affected peers. Their difficulty in performing weight bearing movement skills is hypothesised to explain poorer bone characteristics. This feasibility study examined the impact of a 13-week exercise intervention on tibial bone parameters in adolescents with DCD.Methods: Twenty-eight adolescents with DCD particip...

Objectives: To characterize clinical features and long-term outcome of CRMO, a rare inflammatory bone disease of childhood and adolescence, which forms part of the spectrum of chronic non-bacterial osteomyelitis (CNO).Methods: We studied 33 patients with an established diagnosis of CRMO followed at the Centre for Bone Quality of the Leiden University Medical Center from 1994 to 2018. Demographic and clinical data were collected at presentation and last f...

Areal bone mineral density (aBMD) of the PA spine and proximal femur remained the gold standard for WHO classification of osteoporosis, fracture prediction and patient monitoring. Unfortunately, with age it is not infrequent to observe the presence of degenerative disease such as spinal osteoarthritis which would have a positive artifactual impact on aBMD which could lead to an erroneous interpretation. In a previous study it has been demonstrated that apparently such artifact...

Introduction: Lymphoblastic leukemia is the predominant form of childhood malignancies with survival rates of >80%. Late effects of cancer and treatment can affect endocrine function and may account for acute and chronic impairment of bone health.Aim and design: To assess bone health in pediatric patients after therapy for lymphoblastic leukemia we initiated a clinical trial investigating clinical and biochemical parameters of growth, puberty, bone t...

The aim of the study was to evaluate time-related changes in serum concentration of bone tissue metabolism markers in Polish Large White male pigs. At birth, the piglets were divided into four groups. The first control group (n=7) received physiological saline i.m. (placebo). The second group (NanoCa group; n=7) were administered p.o. with nanopartical calcium (Ace Nano Calcium, NanoTechWorld, Pohang, Korea). The third group (Dex group; n=7) received...