Bone Abstracts

Introduction: Pubertal suppression with gonadotrophin releasing hormone (GnRH) analogue is introduced after onset of puberty in adolescents with gender dysphoria (GD). As puberty is a critical period for bone accrual and changes in body composition, alterations in body composition and bone mass may be observed during treatment.Methods: Thirty-eight adolescents (32/38 assigned females at birth) with GD had dual energy X-ray absorptiometry (DXA) prior to s...

Osteocalcin (OC) plays crucial roles in glucose homeostasis. OC level in the circulation appears to be associated with glucose and fat metabolism – Although still it remains controversial if it are the levels of total OC and/or undercarboxilated OC (ucOC) which present such association. The present study evaluated the levels of ucOC, total OC, leptin and insulin, in 226 overweight or obese (degree I and II) adult non-diabetic women, having levels of glucose (80–110 m...

The aim of the study was to evaluate interrelationships between morphometric, densitometric and mechanical properties of mandible in Polish Merino sheep. Males (n=7) were kept to slaughter age of 5 months of life to obtain mandible. After the slaughter, morphological properties of the mandible such as bone weight and length were determined. Using quantitative computed tomography (QCT) technique and Somatom Emotion, Siemens apparatus, volumetric bone mineral density (v...

Introduction: Hypovitaminosis D is observed in several rheumatic autoimmune diseases, including systemic sclerosis (SSc); nevertheless, data concerning the possible determinants of reduced serum vitamin D levels in this disease are not fully investigated. The aim of this study is to evaluate the relationship between BMD, body mass composition, skin sclerosis, and serum vitamin D levels in two subsets of SSc patients.Patients and methods: 55 Post-menopaus...

The murine osteoprogenitor cell line, KS483 (Percuros, The Netherlands) is a well-established model for investigation of osteoblast differentiation and bone formation processes. The mesenchymal characteristics of this cell line allow it to differentiate into either adipocytes or mature, mineralizing osteoblasts. Various phases can be distinguished during osteoblast differentiation and maturation; namely proliferation, matrix formation, matrix maturation, and mineralization.</p...

Introduction: Vitamin D deficiency is common among elderly subjects and is associated with reduced muscle strength. Although vitamin D deficiency is common among Saudi subjects, knowledge about its role in relation to muscle strength and physical performance is lacking. The objectives of the present study are to determine vitamin D status in a sample of randomly selected healthy postmenopausal Saudi women and to investigate the association between their serum 25(OH)D levels an...

Introduction: Currently, osteoporosis is mainly diagnosed through dual-enargy X-ray absorptiometry (DXA). However, DXA cannot be used for early diagnoses through population mass screenings because of issues related to ionizing radiation employment. Aim of this study is to perform a preliminary clinical validation of a new ultrasound (US)-based method for vertebral densitometry.Methods: A total of 270 women were included in this study according to the fol...

Introduction: To determine bone microarchitecture analysis (BMA) standard curves for wrist and ankle in men and women.Design: EpiReumaPt is an ongoing national, population-based, cross-sectional, epidemiologic study developed by the Portuguese Society of Rheumatology to estimate the prevalence of rheumatic diseases in Portugal. Trained interviewers have been randomly applying a standardized questionnaire to 10 000 subjects at their houses. Selected cases...

Purpose: To evaluate whether calcium and vitamin D intake is associated with 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) serum concentrations or is associated with either the phalangeal dual energy X-ray absorptiometry (pDXA) or the quantitative bone ultrasound (QUS) at the phalanges and the calcaneus in independent elderly men from southwestern Spain.Methods: Serum PTH and 25(OH)D were measured in 199 healthy elderly men (mean age: 73.31...

Background: Surgical treatment of type 2 diabetes, specially in obese patients, has provided good results in the control of blood glucose and Hb1Ac although its effect on bone health is not clear. The aim of this study was to evaluate gene expression of bone remodelling markers in type 2 diabetic Goto-Kakizaki (GK) non-obese rats after gastrojejunal bypass and sleeve gastroplasty, and their relationship with hormonal parameters.Materials and methods: We ...