Bone Abstracts

Over the past decade, many GWAs and meta-analyses were performed to identify genes and regions involved in bone metabolism and in the osteoporotic phenotypes. Nevertheless, the majority of these GWAS results were not tested at any functional level. This study aims to find and study functional regions in the RANK and RANKL genes that encode well-established proteins in the bone remodeling equilibrium. SNPs, chosen for their location in an evolutionary conserve...

There is a growing evidence of the association between HIV infection and fracture risk. Independently of its cause (antiretroviral therapy (ART) or HIV), what remains most important is a prompt diagnosis. Although densitometry is the gold standard, sometimes this technique is not as accurate as necessary in clinical practice. A new validated tool for early and more accurate diagnosis is presented.MethodsIn a HIV group of patients, ...

Irisin is a hormone-like myokine secreted from skeletal muscle in response to exercise. Considering that an intimate relationship between skeletal muscle and bone has been well established and that physical exercise physiologically stimulates the skeleton strengthening, we explored the involvement of Irisin on bone metabolism.Our findings demonstrated that the myokine Irisin improves cortical bone mass and geometry in vivo, supporting the idea t...

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Objective: Osteoarthritis (OA) is a degenerative, slowly developing joint disease. Although clinical indications of OA can vary among different definitions there is a general agreement that the disease is associated with cartilage narrowing. However, there is no general consensus about the threshold below which the joint space width (JSW)/joint space area (JSA) can be certain indicators for the state of OA. Therefore this study evaluates these limits to reveal quantitative inf...

Bisphosphonates are used in the treatment of a variety of diseases with skeletal complications. With the development of more potent compounds, there is the potential for further improvement. One concept is to use compounds with a reduced affinity for bone, reducing their long-term retention and possible adverse events, as well as potentially enhancing their non-skeletal benefits. We hypothesise that a highly potent bisphosphonate with low bone affinity, known as OX14, will be ...

LIGHT (TNFSF14), expressed by different cells of the immune system, binds two trans-membrane receptors: HVEM and LTβR. It is over-expressed in erosive rheumatoid arthritis and lytic myeloma-bone disease and controversial data have been published on its role osteoclast (OC) formation in vitro. Here, we investigated the role of LIGHT on in vitro murine osteoclastogenesis model and bone phenotype in LIGHT−/− mice. Firstly, we showed that murin...

Sclerostin (SCL) and FGF23 are osteocyte-secreted factors with a major role in bone homeostasis. Despite their skeletal effects and their association with fracture risk in some studies, variations in circulating levels were also described in patients with diabetes (DM), chronic renal failure (CRF) and/or cardiovascular disease (CVD). In order to provide further insight on the relationship between these osteocyte-derived factors, osteoporosis and cardio-metabolic disorders we a...

Objectives: Bone mass development through childhood is very important for osteoporosis prevention during adulthood. Physical activity (PA) and/or exercise can influence positively bone matrix and its contents in pre-adolescents Sclerostin, a glycoprotein produced by osteocytes, promotes osteoclastic activity and it is associated with reduced bone formation. The purpose of this study was to describe the relationship between PA and sclerostin levels in pre-adolescent boys and gi...

Introduction: Bisphosphonates are drugs of first choice in the treatment of postmenopausal osteoporosis; they inhibit bone resorbtion.Aim: This study evaluates the efficiency of bisphosphonates (alendronic acid+cholecalciferol 70 mg/5600 IU per weekly vs risedronic acid 35 mg/weekly vs ibandronic acid 150 mg/monthly) after 1 year of therapy.Methods: We present the results of a retrospective study which included 40 women with postme...