Bone Abstracts

Aim: The aim of the research is to define the bone mineral density in patients, with Parkinson’s disease.Methods: We examined 12 women with Parkinson’s disease and 12 healthy women of appropriate age (average age: −63.6±6.25 vs 62.2±6.83 years, P=0.5). The duration of Parkinson’s disease was at list 5 years. All patients reseived levodopa.Results: BMD of women with Parkinson’s disease wa...

Background: Osteocalcin has an important role in bone metabolism. Uncarboxylated osteocalcin predicts risk for hip fracture and lower bone mineral density (BMD). Warfarin inhibits carboxylation of osteocalcin, providing a mechanistic link between warfarin and impaired bone metabolism. Studies examining the relationship between warfarin use and BMD have been inconsistent. The goal of this study was to further characterize this relationship.Population: CaM...

The aims of this study were to analyze the role of the regulators of bone remodeling, OPG and RANKL, in the bone loss associated with recent spinal cord injury (SCI) as well as the effect of antiosteoporotic therapy with denosumab in these bone regulators in a prospective study.Patients and methods: Twenty-three male patients (aged 18–67 years (mean 36±16 years)) with recent (<6 months) complete SCI were prospectively included (43.5% parapl...

Introduction: Mandibular alveolar bone appears to be particularly sensitive to local factors compared to other skeletal sites. In growing rats, occlusal hypofunction leads to a dramatic decrease of the alveolar bone microarchitecture. Intra-radicular bone surrounding teeth is a specific functional area with a high bone turnover. We hypothesized that the mechanical loading of the alveolar process during mastication may play a role in the preservation of the alveolar bone microa...

New food strategies should be developed to fight against child malnutrition and growth retardation in developing countries. Spirulina alga, one of the richest sources of vegetable protein, contains all essential amino acids. It easily grows in tropical regions. We hypothesized that impaired peak bone mass acquisition (PBMA) caused by dietary protein deficiency could be prevented by Spirulina supplementation in growing rats.One-month old female rats were ...

Wnt–β-catenin signalling and its antagonists (sclerostin and Dkk-1) play an important role in the regulation of bone mass and osteoblastogenesis. Glucocorticoid therapy (GCCT) is a well known factor related to decreased bone formation and osteoporosis development. Therefore, we analyzed the effect of GCCT on Wnt signalling antagonists (sclerostin and Dkk-1) and their relationship to bone mass and bone turnover.Methods: 22 patients (11M/11F, age...

Low protein diet (LPD) impairs body growth, decreases serum IGF1 and increases serum FGF21, two hepatokines influencing bone growth. Low calcium-phosphate diet (LCaPiD) increases serum calcitriol. We hypothesized that LPD effects on bone growth may differ according to calcium and phosphate intakes through the hormonal modulation of calcitriol, IGF1 and FGF21. One-month old rats were fed isocaloric diets containing 10 or 5% casein (10Prot, 5Prot), with 1.0% calcium and 0.8% pho...

The objective of this study was to evaluate the ability of various quantitative ultrasound variables to discriminate osteoporotic female corticosteroid users. Thirty-two women aged between 26 and 79 years who have been receiving corticosteroids equivalent to a minimum of 5 mg daily prednisolone for more than 3 months underwent bone mineral density (BMD) measurements at the lumbar spine, hip, and one-third radius (33% radius) using dual-energy X-ray absorptiometry (DXA). Acoust...

Background: In patients with osteogenesis imperfecta (OI), a rise in age-specific total body and regional bone mass is well recognised. In contrast changes in body size-adjusted bone mass in relation to changes in body composition following pamidronate therapy remain relatively unexplored.Methods: Changes in total and regional bone mass in relation to body composition in children with OI receiving pamidronate (3 mg/kg per day over 3 days, 3 monthly) were...

Duchenne muscular dystrophy (DMD) is associated with osteoporosis, and dystrophic (dystrophin-deficient) mdx mice show reduced bone mass characterised by decreased mineral apposition and elevated bone resorption. To investigate a potential role of the G-protein-coupled receptor protease-activated receptor-2 (PAR2) in the muscle and bone pathology associated with DMD, we established a colony of PAR2-null-mdx mice. Limb and diaphragm muscles, tibiae and ser...