Bone Abstracts

Introduction: Nitrogen-containing bisphosphonates (N-BPs) can inhibit the differentiation and function of osteoclasts derived from Peripheral Blood Mononuclear cells (PBMCs) in a dose-dependent manner. MUTZ-3 cells are a potentially useful human cell line for studying osteoclast differentiation. The aim of this study was to elucidate the action of N-BPs on MUTZ-3 cells.Methods: Human PBMCs and MUTZ-3 cells were cultured in α-MEM supplemented with he...

Objectives: Sox9 is a dominant but insufficient transcription factor to induce thorough primary chondrogenesis, so other factors which may induce primary chondrogenesis besides Sox9 have been assumed. The previously reported function of transcription factor Nkx3.2 is to maintain chondrogenic phenotype by suppressing Runx2, while recent studies demonstrated that mouse Nkx3.2 null mice shows severe metaphyseal dysplasia which is similar to that seen in type II collagen a1 (Col2a...

Polynesians have higher bone mineral density and lower rate of hip fracture compared to age-matched Caucasian in New Zealand, and anecdotal evidence suggests that bones of Polynesian patients heal much faster than those of Caucasians. We compared gene expression in osteoblasts cultured form bone samples taken from patients of Polynesian and Caucasian origin, in order to identify genes and pathways that contribute to the greater density and accelerated healing of Polynesian bon...

Introduction: The purpose of this study was to determine osteoporosis (OP) and osteopenia in patients with various rheumatic diseases depending on the duration of use glucocorticosteroids (GCS) and daily dose of GCS.Methods: The study included 125 patients (90 women and 25 men) with various rheumatic diseases receiving GCS therapy. BMD was measured by DXA (Hologic). Patients were divided into two groups. Group I included postmenopausal women and men over...

Introduction and objectives: Male osteoporosis in the Arab World and the Middle East should be considered a major public health issue, and a problem in clinical medicine which deserves adequate attention similar to post-menopausal osteoporosis. There is a great lack of awareness among men about osteoporosis, and treatment is not as well codified as in women.The aim of this study was to evaluate referrals of male patients to Osteodensitometry Unit in a Un...

Type 2 diabetes and osteoporosis often occur together in postmenopausal women. Sitagliptin is a new drug used in the therapy of type 2 diabetes; it affects incretin system as a result of inhibition of dipeptidyl peptidase-4. So far, the impact of the drug on bone remodeling processes is unknown. The aim of this study was to investigate the effect of sitagliptin on bone growth and remodeling in non-ovariectomized and ovariectomized rats.The experiments we...

Introduction: The authors experienced a ipsilateral femoral stress fracture after total knee arthroplasty (TKR). Decreased bone mineral density (BMD) after TKR have been proposed as cause. However, reports regarding changes of BMD in the proximal hip after TKR have been rare. Therefore, first, we studied the question of whether TKR can effect change of proximal hip BMD? Second, if so, does TKR have different effects on BMD of the operative and non-operative sides?<p class=...

Introduction: To compare serum vitamin D levels in elderly patients with or without osteoporotic spinal compression fractures (OSCF) and to evaluate a correlation between serum vitamin D level and several variables such as age, and bone mineral density (BMD), bone turnover markers.Methods: The medical records of 78 patients with OSCF (fracture group) and 84 age-matched control patients who were diagnosed osteoporosis without OSCF (control group) were rev...

Ancient Egyptians were well known for the art of embalming, performed in the belief that preservation of the body was essential for survival in the afterlife. During the mummification process, internal organs were removed and some of them (lungs, stomach, liver, and intestines) washed, dehydrated with natron, perfumed, and stored in so-called canopic jars, buried with the mummy. Each jar had established contents and its own protective deity. To date, a limited number of studie...

Background: Glucocorticoid immune suppression in kidney transplanted children jeopardizes optimal bone health recovery. So far, there are no studies that evaluate the effect of transplant and corticoid in bone parameters separately.Objective: To determine the effect of early corticosteroid withdrawal in bone parameters.Methods: Randomized, controlled study; two groups: corticosteroid withdrawal (at the 6th day post-transplant, then...