Bone Abstracts

Senile osteoporosis and age-related osteopenia are associated with decreased osteoblastogenesis and increased bone marrow adipogenesis. The mechanisms controlling the fate determination of osteoblast to adipocyte differentiation of bone marrow stromal cells (BMSC) during aging are not known. We and others previously showed that the cell-cell adhesion molecule N-cadherin (N-Cadh) expressed in osteoblasts controls bone formation, but little is known about its role in BMSC fate d...

Introduction: Mesenchymal stem cells (MSCs) counteract the decline of physiologic functions but their regenerative power decreases with age. In particular osteogenic differentiation capacity of MSCs has been shown to decrease with age thereby contributing to slowed down bone formation and osteoporosis. While much is known about cellular aging of MSCs, little is known about extrinsic factors influencing their functionality. Here we set out to identify circulating factors of the...

Background: The optimal level of 25-hydroxyvitamin D2 (25(OH) D) for a healthy bone is not clear, nor the effects of treatment with vitamin D. Few previous studies have measured treatment effect on BMD in young deficient individuals.Materials and methods: A treatment group of vitamin D deficient immigrant women and a control group of ethnic Swedish women were recruited during pregnancy. A treatment of 800–1600 IU cholecalciferol and 500–1000 mg...

Objective: Accretion of bone mass in childhood is dependent on both bone modeling and remodeling. We recently found that preosteoclasts secrete platelet derived growth factor type BB (PDGF-BB) to promote angiogenesis coupling with osteogenesis during both modeling and remodeling. As secretion of PDGF-BB by preosteoclasts can be enhanced through inhibition of cathepsin K activity to increase bone mass in adults, we explored if increase of secretion of PDGF-BB by preosteoclasts ...

Osteoporosis is a chronic disease with a high prevalence in older adults. There is evidence that statins have some beneficial effects on bone metabolism. Although the trial reports are ambiguous, it is now accepted that statins block the osteoclast differentiation inhibiting to some extent bone resorption. Our aim was to evaluate the effects of a statin in an animal model, which was induced to osteoporosis by glucocorticoids and then treated with atorvastatin. The experimental...

Objectives: • To establish the child and family experience of attending multi-disciplinary clinics within the rare bone disease service at Evelina London Children’s Hospital.• To gain an understanding of the daily challenges the children, young people and families face.• To understand how the tertiary multi-disciplinary team may support the child, young person and family.<p class="ab...

Objectives: Impairment of bone mass accrual and alterations of bone metabolism is a common finding in HIV-infected youths. In particular, previous studies demonstrated higher bone formation and bone resorption rates in HIV-infected children and adolescents. Wnt ligands promote bone formation by stimulating osteoblast differentiation and their survival. Recent studies demonstrated that sclerostin (Scl) and dickkopf factor 1 (DKK-1), Wnt antagonists, are important negative regul...

Objectives: To examine the bone mineral density (BMD) response to i.v. pamidronate (Group 1) vs i.v. zoledronic acid (Group 2) in non-ambulatory children and young adults with severe cerebral palsy or other neuromuscular disorders.Methods: A total of 50 non-ambulatory children and young adults, (mean age 11.3 years, range 2.1–32) with low BMD and/or history of fractures were retrospectively studied. Thirty-nine patients (30 spastic quadriplegic cere...

Biographical DetailsDr Madhusmita Misra is a full Professor of Pediatrics at Harvard Medical School and a Pediatric Endocrinologist at Massachusetts General Hospital in Boston, Massachusetts. She directs the fellowship training program in Pediatric Endocrinology at Massachusetts General Hospital, and has a Masters in Public Health from the Harvard School of Public Health. Dr M Misra’...

Osteoporosis in premenopausal is dominated by secondary causes, among which anorexia nervosa, the female athletic triad, celiac disease, and glucocorticoid-induced osteoporosis (GIO) constitute the most frequent conditions. Stress fractures of the lower extremities and low energy fractures of the ribs, are also frequent. Various genetic causes like osteogenesis imperfecta tarda are probably underdiagnosed and various inflammatory conditions also play a role. A rare, but often ...