Bone Abstracts

Biographical DetailsSogol Mostoufi-MoabI am an Assistant Professor of Pediatrics at the Children’s Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, and board certified in pediatric oncology and endocrinology. I have advanced epidemiology training and my research program is focused on bone, body composit...

Backgound: Limited data are available on body composition of preterm compared to born at term infants. The aim of our study was to compare bone mass, fat mass-FM and free fat mass-FFM in preterm and term infants at 40th weeks of gestational age (GA).Methods: Thirty-four preterm infants (14M, 20F) born at 31.0±2.2 weeks of GA (range 26–36+3 weeks) and n=8 term neonates (4M, 4F) born at 39.7±1.0 weeks of GA underwent a to...

Being efficient and productive in research is frequently linked to a structured organization of the available research time. This applies to any individual scientist including PhD students, Postdocs, or PIs. In particular PIs but also to some extend more senior Postdocs have a responsibility for more junior scientists and in the case of PIs even of an entire research team. This does not only require overseeing and organizing his own time but also the time and workload of other...

Objectives: To describe two familiar cases of Hajdu–Cheney syndrome, a rare genetic disorder associated with skeletal dysplasia, craniofacial abnormalities, short stature, acro-osteolysis and osteoporosis.Materials and methods: A 51-year-old woman (case 1) presented in our outpatient clinic with pseudo-clubbing of some fingers and toes. She was short (139 cm) and thin (34 kg). She had facial and cranial abnormalities: thin lips, long philtrum, full ...

Background: Osteoporosis is a leading cause of morbidity in patients affected by β-thalassaemia major (TM) and intermediate thalassaemia (TI). Appropriate supportive care and identification of long-term sequels of therapy are important in thalassaemic patients. As low bone mineral quality (BMQ) in patients can be considered a marker of possible degeneration to osteopenia and osteoporosis in adulthood, we evaluated bone features in a young population followed at ‘A. P...

Objectives: The aim of the study was to establish features of macroelemental composition of the dentin in mature male rat’s mandibular incisors with biogenic hydroxyapatite, implanted in the proximal part of tibial shaft.Material and methods: One hundred and twenty-six mature male rats were divided into three groups: 1st group – intact animals, 2nd group – animals with the pit defect applied on the proximal part of tibial shaft (systematic...

OPTN encodes a cytoplasmic protein optineurin which has been shown to play a role in autophagy. Recent GWAS studies have shown that variants within OPTN are associated with the risk of Paget’s disease of bone, a disease characterized by focal areas of increased bone turnover due to increased osteoclast activity, suggesting a possible role of OPTN in the regulation of bone metabolism.The aim of this study was to investigate the role of optineurin in ...

Background: We have previously shown that MLO-Y4 osteocytes express a number of P2 receptors, respond to a broad range of nucleotides (e.g. UTP) by increasing intracellular calcium concentration and release ATP upon both mechanical and UTP stimulation. The aim of this study therefore is to investigate how the osteocytes release ATP and whether there is a difference in release pathway depending on the type of stimulus.Methods: ATP release was investigated...

Osteocytes differentiate from osteoblasts, are embedded in mineralised matrix and are critical regulators of bone remodelling. In vitro osteocyte models are limited to cell lines in monolayer, which do not represent their 3D environment in vivo. We have shown that osteoblasts in 3D gels differentiate along the osteocytic pathway. Since IGF1 regulates osteoblasts, and is involved in osteocyte response to mechanical loading, we hypothesised that IGF1 modulates ...

Calcium represents one of the most versatile and universal signalling particles regulating many different cellular processes. Changes in [Ca2+]i give rise to a vast diversity of modulatory events, amongst others, influencing activities of kinases and ion channels.It was demonstrated that nuclear magnetic resonance therapy (NMRT) treatment in osteoarthritis led to reduced pain and improved function followed by increase in quality of ...