Bone Abstracts

Objective: Patan, is a semi urban area in Gujarat, India where fluorosis is endemic (Fluoride concentration in ground water 1.96–10.85 ppm, Patel et al., 2008). Exposure to fluoride is likely to be higher in lower socio-economic class (SEC) due to lack of access to bottled water. Calcium intake and vitamin D status may modify fluorine absorption. Therefore, the aims of this study were to examine: i) prevalence of dental and skeletal fluorosis in children from upper, middl...

Background: Low vitamin D concentrations among children and adolescents at northern latitudes are frequently observed. Also, inverse associations between 25-hydroxyvitamin D (25(OH)D) and PTH concentrations have been found in children of different ages. More studies on the link between vitamin D status and childhood bone health are needed.Objective: To evaluate the status of serum 25(OH)D in autumn and the association between 25(OH)D concentrations and b...

Objectives: Young male jockeys undertake calorie restriction and high volumes of physical activity during periods of musculoskeletal growth and development. Previous research shows that jockeys have compromised bone health1–4 and display disordered eating5–7. Restricted intakes of calcium and vitamin D, together with excessive amounts of exercise, increase the risk of osteoporosis in males8. The aim of this study was to establish whet...

Background: In the National Osteoporosis Guide 2014 all the patients are first recommended adequate calcium and vitamin D intake. For additional treatment US FDA approves the use of medications within seven different drug groups, but no magnesium. We have therefore studied the beneficial effect of Mg added to a Ca/vitamin D regime.Study: Fifty healthy women aged above 70 years recruited from elderly center were randomized into a Mg supplementation group ...

Background: Vitamin D deficiency is highly prevalent and can be associated with adverse health outcomes. Few studies have evaluated the effects of daily consumption of milk fortified with a high dose of vitamin D in a large cohort of healthy postmenopausal women.Objectives: To determine the effect of daily intake of milk enriched with vitamin D (with or without fructooligosaccharides (FOS)) on vitamin D status, bone mass and cardiovascular risk factors.<...

Objective: To study association of VDR gene Fok1 polymorphism locus on bone mass accrual in adolescent girls.Methods: An intervention trial was carried out in 102 girls aged 8–16 years (Pune, India). All girls received 500 mg elemental calcium (daily) and 30 000 IU of vitamin D3 quarterly for 1 year. Outcome variables were measured at baseline and end of the year. Serum levels of ionised calcium (iCa), inorganic phosphorous, parathyroid hor...

Fibroblast growth factor-23 (FGF23) is a hormone originating from osteocytes with suppressive actions on renal phosphate reabsorption and vitamin D synthesis. We recently identified FGF23 as a calcium-conserving hormone, regulating the membrane transport of the epithelial calcium channel TRPV5 in distal renal tubules. Here, we analyzed the long term sequelae of Fgf23 deficiency and renal calcium wasting on bone and mineral metabolism in 9-month-old mice lacking both Fgf23<...

Arterial stiffness or pulse wave velocity (PWV) is increasingly recognized as a strong predictor of future cardiovascular events and all cause mortality. Literature date indicate a relationship between vitamin D (25-OHD) deficiency and arterial stiffness in isolated systolic hypertension (ISH), but it is still unclear how 25-OHD deficiency may contribute to functional changes of the arterial wall in hypertensive patients. This study aimed to evaluate the relationships between ...

Objective: Although obesity is a risk factor for vitamin D insufficiency, its impact on vitamin D-binding protein (DBP) concentration, and thereby possibly also on free 25OHD, is less well known. Our aim was to compare total and free serum 25OHD, and DBP concentrations between obese and normal-weight young adults at baseline, and their responses to cholecalciferol supplementation.Design: A 12 weeks’ randomized, double-blinded clinical trial.<p c...

Background: Vitamin D-dependent rickets type 1 (VDDR-1) is a rare autosomal recessive disorder caused by mutations in CYP27B1. This gene encodes the 1α-hydroxylase enzyme which converts 25-hydroxy vitamin D to the active form 1,25-dihydroxyvitamin D.Objective: To describe a case of VDDR-1due to a novel CYP27B1 mutation.Presenting problem: A 27-month-old female was admitted to the Pediatric Intensive Care Unit...