Bone Abstracts

Background: Among body composition phenotypes there is no consensus on definition and consequences of sarcopenic obese phenotype. The recommended method to quantify the muscle mass is the dual energy X-ray absorptiometry (DXA), based on measurement of total fat mass and appendicular lean mass. A high BMI may provide a great bone mineral density (BMD) in many individuals, but it does not guarantee optimal bone strength. The aim of our study is to investigate the influence of sa...

Objectives: To explore the benefits of a group circuit therapy programme for children with osteogenesis imperfecta (OI) who have been identified as having functional difficulties resulting from hypermobility, reduced muscle strength, poor cardiovascular (CV) fitness and lack of engagement in physical education.Methods: 16 families were contacted to ascertain interest and preference on frequency and location for a proposed therapy group. Subsequently ten ...

Background: Non-surgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (Ps-HypoPT) are both rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively.Studies on Quality of Life, QoL, are sparse, but studies have shown an increased risk of fatigue and depression.Methods: Using the Danish version of SF36v2 and WHO-5 Well Being Index, we investigated the physical and mental QoL among patients with NS-Hypo...

Objectives: Children with Perthes disease may present with altered walking patterns even at the healed stage of the disease. The aim of the study was to assess the walking endurance, fatiguability and gait changes of children with healed Perthes disease, and to determine if walking endurance is associated with hip function and quality of life.Methods: Fifty-one children (38 males) aged 8–16 years with >3 years post-diagnosis of Perthes disease c...

Background: Juvenile Paget’s disease (JPD) is a rare autosomal-recessive condition. The disease is typically diagnosed in infants or young children and characterized by a generalized increased in bone turnover, bone pain, skeletal deformity and increased risk of pathological fractures. In our knowledge, inactivating mutations in the TNFRSF11B gene, which encodes osteoprotegerin, cause JPD, yet. There are no randomized controlled trials which to offer the optimal form of t...

Introduction: Fibrous dysplasia (FD) of bone is a benign, non-inheritable disease characterized by bone pain, bone deformities and fractures. Its prevalence is ~1 in 30 000 individuals and diagnosis is based on the clinical and radiologic findings and is confirmed by biopsy. Yet, in some cases biopsy is not applicable.Case report: A young woman presented to our outpatient clinic with a history of pain localized at the distal half of the left tibia that h...

Fibrodysplasia ossificans progressiva (FOP) or miyositis ossificans progressiva is a hereditary mesodermal tissue characterized by progressive ossification of striated muscle, tendon, ligament, fasciae, aponeurose and occasionally skin. A single common heterozygous mutation has been identified in the cytoplasmic domain of activin receptor IA/activin-like kinase 2 (ACVR1/ALK2). FOP is very rare with a worldwide prevalence of ~1 case in 2 million individuals. Diagnosis is based ...

Background: This study was designed to investigate the process of bone formation caused by implantation of octacalcium phosphate (OCP) in rat tibiae.Methods: We used 25 young male Sprague–Dawley rats. A full thickness standardized trephine defect, 3-mm in diameter, was surgically created on the superior end of right and left tibia. Amount of 6-μg synthetic octacalcium phosphate was implanted into a bony defect on the right tibia as an experimen...

The childhood and adolescent years represent a critical period for bone acquisition. Extrinsic factors such as diet and physical activity represent modifiable variables that may have a significant impact on a young adult’s peak bone mass. This lecture will consider dietary supplementation with specific nutrients as a strategy to augment bone density during the childhood and teenage years. An overview will be provided, as well as data reviewed from supplementation trials i...

The close relationship between muscle and bone has long been recognized especially during development where one tissue does not develop in the absence of the other. The mechanical interactions between the two tissues have dominated research under the assumption that the major interaction between the two tissues was the loading/unloading of bone by muscle. Though clear that loading of bone by muscle is necessary to maintain healthy bone, the concept that bone could have positiv...