Bone Abstracts

Objectives: The regulation of fibroblast growth factor 23 (FGF23) metabolism during infancy is inadequately characterized. We previously observed a distinct sex difference in intact FGF23 at 3 months of age. In this study we aimed to further examine the role of sex and iron status in FGF23 metabolism in 1-year-old children.Methods: This was a cross-sectional study including 731 1-year-old Caucasian children participating the Vitamin D intervention in inf...

Adolescents with cerebral palsy (CP) have altered muscle tone and reduced bone mass, which can lead to impaired mobility and function increasing their risk for osteopenia in later life. OBJECTIVES: We evaluated the efficacy of two side-alternating vibration therapy (VT) protocols (9 minutes/day versus 15 minutes/day) over a 20-week program on mobility and bone health in adolescents with mild CP. METHODS: Sixteen participants (12.4±0.9 years; 10 males) with mild cerebral p...

Introduction: Paget’s bone disease (PBD) is the second most prevalent metabolic bone disease. Most patients present with pain or fracture but many remain asymptomatic. Evidence suggests a significant reduction both in its prevalence and clinical severity. Recent papers described differences in clinical course and therapeutic options in the last 10–15 years.Objective: To characterize PBD differences between patients having been diagnosed before ...

Introduction: The body composition at term equivalent age of infants born preterm is different than that of infants born at term.Aim: The aim of the study was to compare the body composition in preterm and full-term infants at age 3 and 4 years.Patients and methods: Total body bone mineral content (TBBMC, g), density (TBBMD, g/cm2), and body composition (fat mass – FM, g; lean body mass – LBM, g) were measured ...

Tumour necrosis factor receptor associated factors (TRAFs) play a key role in signal transduction in mammalian cells. Several members of the TRAF family have been identified but only TRAF2 and TRAF6 are implicated in the regulation of osteoclastogenesis. Here we studied the role of TRAF2 and TRAF6 in breast cancer induced bone cell activity and osteolysis. We observed that TRAF2, but not TRAF6, is highly expressed in the human MDA-MB-231 (MDA-231) bone-seeking breast cancer ce...

Background: Bone marrow (BM) adiposity is inversely related to bone mineral density and increases with ageing and menopause. We previously observed that the variation in BM fat fraction was more pronounced in premenopausal women compared to men and postmenopausal women. We hypothesized that the variation in BM fat fraction in premenopausal women is associated with hormonal variations during the menstrual cycle.Objective: To investigate the dynamic change...

The effects of neonatal thymectomy, at 3 days of age, on skeletal sexual dimorphism and bone quality during the development were examined in male and female Wistar rats. Rats were euthanized at 20, 40, or 120 postnatal days and femurs were collected. The Biomechanical compression test was used to evaluate bone breaking strength, energy-to-fracture, and extrinsic stiffness. During the prepubertal period, the neonatal thymectomy increases extrinsic stiffness of bone tissue signi...

Objectives: The aim of this study was to evaluate the association between the age at onset of walking and bone mineral content (BMC) in healthy 2-year-old children participating in the Vitamin D in Infants Trial (VIDI).Methods: Altogether 253 children (120 girls, 133 boys) with a daily vitamin D3 intake of 10 μg and a sufficient serum 25-hydroxyvitamin D (25-OHD) concentration (>50 nmol/l) were included in the analysis. BMC was measur...

Biographical DetailsDr Brendan Lee is the Robert and Janice McNair Endowed Chair in Molecular and Human Genetics, Professor and Interim Chairman of the Department of Molecular and Human Genetics at Baylor College of Medicine. Dr B Lee co-directs the joint MD Anderson Cancer Center and Baylor College of Medicine Rolanette and Berdon Lawrence Bone Disease Program of Texas, and the Baylor Co...

Background: Cardiovascular disease is the leading cause of death in pediatric (ped) and adult ESRD patients. Left ventricular hypertrophy (LVH) is an independent predictor of mortality in ESRD. Besides traditional risk factors, such as high BP & fluid overload, high plasma FGF23 is associated with LVH in adult ESRD patients. Little is known about Kl, the renally produced cofactor of FGF23 for phosphorus (P) homeostasis. We studied ped HD patients for risk factors for LVH, ...