Bone Abstracts

Bisphosphonates are the mainstay of medical therapy in the fracturing child with osteoporosis. The majority of the data in children pertains to i.v. pamidronate use in children and adolescents with osteogenesis imperfecta (OI), where pamidronate has been associated with improvements in bone mineral density, cortical thickness, vertebral shape, pain, mobility and height.1 Side-effects of pamidronate including acute phase response to the initial dose and retardation o...

Objective: The physis, or growth plate, is comprised of precisely organized chondrocytes that confer longitudinal growth of the bone. Multiple signaling pathways cooperate to regulate growth through their control of chondrocyte shape, polarity, proliferation, and differentiation.1,2 Disruption of these cellular events result in physeal defects, skeletal deformities, and abnormal limb growth. Loss of function mutations in Smad4, a common intracellular effector of all...

Sclerostin is a major negative regulator of osteoblastic activity. Serum sclerostin has a weak positive association with BMD but contradictory results have been described concerning associations with fractures. These contradictions could be explained by the fact that serum sclerostin does not reflect its action in bone. In this study we question whether serum sclerostin is associated with its expression in bone. In addition we aimed to detect associations between sclerostin in...

Objectives: Evaluation of influence the structural and functional condition of bone tissue on caries intensity in adolescents living with deficient of fluoride in drinking water (<0.4 mg/l).Methods: It was examined 200 school children (12 and 15 years old) living in Transcarpathian region.Oral examination was done to determine caries intensity in the subjects (DMFT-index). Bone quality was determined using quantitative ultrasou...

Objective: To study any possible relations of vitamin D status and metabolic syndrome (MetS) components in children, since there is evidence for extraskeletal functions of vitamin D, and its deficiency may contribute to the pathogenesis of several major diseases. In addition to explore any possible role of birth weight (BW).Methods: Clinically healthy children aged 3–9 years (n=152) were included in the study. Forty-six were born large for ...

Introduction: Most studies to date have focus on the effect of exercise interventions on bone remodeling. Furthermore, inflammation has been associated with those critical for bone physiology and remodeling. However, investigations analyzing the relationship between objective physical activity and bone metabolism and inflammatory markers and the potential interactions with BMD and body composition in older men are limited, which is the aim of the present study.<p class="ab...

Women suffer more fragility fractures in old age and have a higher incidence of fractures at the femoral neck region compared to men who have higher incidence of trochanteric femoral fractures. The purpose of this cross-sectional study was to analyze associations between physical activity (PA) and bone mass distribution at the femoral neck (FN) and trochanter (TR) in young adults. A left hip DXA scan was used to measure bone mineral density (BMD) at the integral, superolateral...

Background: The ‘adequate’ level of 25-hydroxyvitamin D (25OHD) in children remains unclear. For bone outcomes, parathyroid hormone (PTH) is an important functional biomarker. Prior studies have shown too weak a correlation between 25OHD and PTH levels to determine adequate 25OHD level.Objective: To determine adequate 25OHD level(s) in children using a normal PTH value of 65 pg/ml while adjusting for calcium intake.Design...

The R-spondins are a family of four small, secreted agonists of the Wnt signaling pathway. Growing evidence from both in vitro studies and in vivo models supports the major role of these proteins in the skeletal development processes. In humans, common genetic variation in the RSPO3 gene has been associated with BMD in large scale GWAS study.This study aimed at further investigation of the genetic and functional contributions of the R-s...

Peak bone mass, typically reached in the third decade, is the highest bone mass acquired after completion of normal growth. Attaining a higher young adult bone mass may contribute to a lower risk of fragility fractures later in life. Few studies have specifically investigated quantitative ultrasound (QUS) in relation to peak bone mass in young adult women. The study objectives were to describe normative QUS values for 25 year old women and how extremes of body weight relate to...