Bone Abstracts

Proprotein convertase PC5/6 (Pcsk5) is expressed in mouse bone and Pcsk5 epiblast-specific conditional knockout mice have a bone phenotype displaying small size, delayed ossification and additional thoracic segments and ribs. Some features are attributed to growth and developmental factor 11 (GDF11) – a known substrate for PC5/6 – while the delayed mineralization has yet to be explained. Osteopontin (OPN) is a bone matrix protein with roles in miner...

It has been recently reported that, after physical exercise activity, the skeletal muscle releases Irisin, the newly identified myokine able of driving transition of white adipocytes to brown, following a phenomenon known as the browning response. This result has suggested that skeletal muscle is crucial in the regulation of energy homeostasis, supporting the idea that it can be considered an endocrine organ that targets adipose tissue by promoting energy expenditure. In accor...

Aim: Aim of our study was to investigate the serum adiponectin, leptin, and osteoprotegerin (OPG) levels and its expressions in the adipose tissue, and their relationships with bone metabolism and in patients with severe C chronic obstructive pulmonary disease (COPD).Materials and methods: Serum leptin, adiponectin, OPG, the receptor activator of nuclear factor-kB ligand (RANKL), and bone turnover markers (osteocalcin and type 1 collagen C-telopeptide (C...

Objectives: Studies have reported prevalence of vitamin D deficiency in Indian children with adequate sunlight exposure (Harinarayan, 2008). The objectives of our study were to A) examine the prevalence of vitamin D deficiency in children with adequate sunlight exposure in a semi-rural setting in Western Maharashtra (18(°N), India and B) explore the association of serum 7-Dehydrocholesterol reductase (7-DHCR) with the serum vitamin D levels.Methods:...

Objectives: Skeletal mass approximately doubles at the end of adolescence. Low areal bone mineral density (BMD) associated with vitamin D deficiency may be highly prevalent in some regions of the world. The aim of this study was to investigate effects of different socioeconomic conditions on BMD and vitamin D status in healthy Turkish female university students and to determine an association between Vitamin D status and BMD.Participants and methods: We ...

Several cell types form the hematopoietic stem cell niche. These niches sometimes become hijacked by cancer cells, which may later form metastatic lesions. Our aim was therefore to characterize the bone marrow microenvironment to affect cancer cell homing to bone marrow.Pharmacologic modification consisting of PTH to stimulate the osteoblasts and zoledronic acid to prevent the increase in osteoclasts through PTH resulted in increased homing of cancer cel...

Sclerostin, encoded by the SOST gene, functions as an inhibitor of the Wnt pathway and thus it is an important regulator of bone homeostasis. The fact that osteoblasts, the only cells expressing SOST, lay buried deeply in the bone matrix, poses intrinsic difficulties to the study of the regulation of this gene. Since RUNX2 and SP7/OSX are two known regulators of the differentiation of cells of the osteoblastic lineage, the aim of this study was to determine t...

LIGHT (TNFSF14), expressed by different cells of the immune system, binds two trans-membrane receptors: HVEM and LTβR. It is over-expressed in erosive rheumatoid arthritis and lytic myeloma-bone disease and controversial data have been published on its role osteoclast (OC) formation in vitro. Here, we investigated the role of LIGHT on in vitro murine osteoclastogenesis model and bone phenotype in LIGHT−/− mice. Firstly, we showed that murin...

Introduction: This study aims to assess 25-hydroxyvitamin D—25(OH)D—status in perimenopausal women to analyze its relationships with serum PTH levels and bone mineral density (BMD).Methods: A total of 102 individuals who visited to climacteric clinic in Sanggye paik hospital participated in the study. Serum 25(OH)D and intact parathyroid hormone (PTH) were measured. BMD was determined by dual x-ray absorptiometry (DXA) at lumbar spine, femoral ...

Background and Aim: Smoking increases fracture risk and contributes to COPD-associated osteoporosis. However, its impact on bone metabolism is largely unknown. We thus aimed to determine the effect of smoking cessation on bone metabolism.Subject and Method: In this prospective study, we recruited 29 healthy Japanese male subjects with smoking habit (37.7±8.2 years old, 16.9±11.3 pack years). Pulmonary function test was done before smoking cessa...