Bone Abstracts

Background: In the National Osteoporosis Guide 2014 all the patients are first recommended adequate calcium and vitamin D intake. For additional treatment US FDA approves the use of medications within seven different drug groups, but no magnesium. We have therefore studied the beneficial effect of Mg added to a Ca/vitamin D regime.Study: Fifty healthy women aged above 70 years recruited from elderly center were randomized into a Mg supplementation group ...

Purpose: Denosumab is commonly used as an anti-resorptive agent to treat osteoporosis. After discontinuation of denosumab, however, bone resorption increases again, and the bone mass gained during therapy is lost within a year.Methods: We present a case report of asymptomatic hypoparathyroid hypercalcemia in a patient who discontinued long-term treatment with denosumab.Results: A 67-year old women with osteoporosis was treated with...

Objectives: Osteogenesis imperfecta (OI) is a bone fragility disorder associated with reduced muscle size, dynamic muscle function and mobility. This paired randomised controlled pilot study assessed the effect of whole body vibration (WBV) training on bone density and geometry, muscle size and function, mobility, and balance in children with OI.Methods: Twenty-four children (5–16 years) with OI types 1,4 and limited mobility (defined as a Childhood...

Objectives: The regulation of fibroblast growth factor 23 (FGF23) metabolism during infancy is inadequately characterized. We previously observed a distinct sex difference in intact FGF23 at 3 months of age. In this study we aimed to further examine the role of sex and iron status in FGF23 metabolism in 1-year-old children.Methods: This was a cross-sectional study including 731 1-year-old Caucasian children participating the Vitamin D intervention in inf...

Background: X linked hypophosphataemic rickets is the commonest cause of renal phosphate wasting, however sporadic cases may warrant additional investigations to exclude less common causes, as exemplified by our case.Presenting problem: A 3 year 7 month boy was referred for assessment and ongoing management of rickets and short stature (height less than 1st %.) He originally presented with leg bowing and waddling gait from the age of 12 months...

Assessment of metaphyseal bone growth in children by peripheral quantitative computed tomography (pQCT) is limited by use of a thin (2.3 mm) 2D slice to represent the ~20 mm metaphyseal region within which there is substantial local variation in bone properties (Marjanovic et al., 2009). In addition, scan positioning is performed by manual visual growth plate identification from which a region located proximal to the growth plate at 4% of tibia leng...

Gross motor development is positively associated with bone mineral density in teenagers and is thought to be mediated by lean mass. Age at walking is an accepted milestone in motor development, achieved by 50% of infants by 12 mo of age according to the WHO Motor Development Study.Objective: To examine if walking within 12 mo of age is related to bone mineral density (BMD) and if this relationship is mediated by lean mass.Methods: ...

Background: Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive metabolic disorder affecting amino acid transport. The condition typically presents at weaning, with recurrent diarrhoea and vomiting especially following protein rich meals. It may have a multisystem clinical presentation including growth and haematological abnormalities and rarely osteoporosis. The diagnosis is based on biochemical findings, including increased urine and reduced plasma concentratio...

Mechanical loading exerts a major influence on the size, shape and structure of the skeleton attained in early adulthood, an important determinant of osteoporotic fracture risk in later life. In studies of exercise interventions in children intended to optimise skeletal development, activities associated with relatively high impacts are generally more effective, in line with findings from laboratory studies that bone is exquisitely sensitive to high impacts producing transient...

Biallelic ENPP1 deficiency in humans induces hypophosphatemic rickets in children characterized by increased circulating FGF23 levels and renal phosphate wasting (‘Autosomal Recessive Hypophosphatemic Rickets Type 2’, or ARHR2), but osteopenia or osteoporosis has not been described in adults. Here, we describe three adult male patients (ages 43, 59, and 62) suffering from early-onset osteoporosis who presented to the Institute of Osteology and Biomechanics at the Uni...