Bone Abstracts

Bones’ fracture resistance is achieved in vivo by adaptation to habitual loading. Aged bone can adapt to exercise1 but in female rodents ageing impairs the adaptive response to artificial loading2,3. This inconsistency led us to investigate whether treadmill exercise, sufficiently mild to not itself stimulate new bone formation, could rescue aged bone’s diminished response to artificial loading.Young adult 17-week...

Osteocytes make up >90% of bone cells, are embedded in mineralised matrix where they form a communication network. Osteocytes differentiate from osteoblasts, and are mechano-sensitive. They are very difficult to isolate with a dependence on cell lines for in vitro studies of osteocyte biology. Therefore new methods to study these cells are essential. Recent publications indicate that osteoblasts maintained in in vitro 3D collagen gels may differentiate to...

Objective: Optimal intakes of calcium and milk are necessary in children and adolescents to facilitate not only mineralization but also growth in stature. Low intakes of calcium and also, of milk and milk products in Indian children have been reported. Hence, the objective was to study Indian children’s growth with respect to their calcium and dairy intakes.Methods: We studied 220 children (boys 104, age range 2–16 years). Data on their height,...

Background: Mechanical stimulation is thought to be critical for bone anabolic activity. It is unclear how quickly the growing skeleton responds to additional externally-applied mechanical stimuli. We wished to determine the acute effect of a standardised mechanical stimulus to the growing skeleton.Objectives: To determine the acute time course and magnitude of bone’s response to whole body vibration (WBV) in pre-pubertal boys.<p class="abstext"...

Background and aims: Bone turnover markers (BTMs) are used in clinical practice for assessing patients with osteoporosis and their treatment. In Spain it is necessary to fine-tune the reference intervals, since they were established years ago in a low number of individuals. The aims of this study were to establish robust reference intervals for BTMs in healthy young premenopausal Spanish women and to investigate the factors influencing BTMs.Methods: 185 ...

Introduction: Clinical practice guidelines recommend a daily intake of calcium of 1-1, 5 g for posmenopausical osteoporosis. However, giving the possible adverse effects of calcium supplements, their use remains controversial.Aims: Validate the dietary assessment of calcium. Evaluate the degree of compliance of the medical advice and discuss the adequacy of prescribing calcium supplements.Patients and methods: Sample cohort compris...

Objectives: Previous studies have reported that the rise in parathyroid hormone (PTH) concentrations may be used to determine the levels of vitamin D adequacy. However, dietary calcium intake may also influence the rise in PTH. In the light of low calcium intakes in Indian adolescents, our aim was to investigate the relative importance of calcium intake in relationship of serum 25 hydroxyvitamin D (25OHD) with intact serum PTH in apparently healthy children.<p class="abste...

Context: An increase in bone marrow adiposity (BMA) is usually described in anorexia nervosa (AN) patients and in calorie restriction models. This induced BMA could be involved in the development of the osteoporosis often described in AN. However, BMA increase is not always observed and could be depending on the severity of the deficit.We previously developed the separation-based anorexia mouse model (SBA)1 (Ethical approval CEEA #022012). SBA...

: Osteonecrosis of the jaws (ONJ) is a relatively new adverse effect associated with bisphosphonate therapy, but no causal association has been established. By definition, a patient is considered to suffer from ONJ if he has current or previous treatment with a bisphosphonate, exposed bone in the maxillofacial region that has persisted for more than 8 weeks and no history of radiation therapy to the jaws. It has been proposed that ONJ could be linked with impaired topical immu...

Safety data on zoledronic acid (ZA) administration for osteoporosis suggest potential kidney toxicity; indeed, it is not indicated in patients with impaired renal function. Patients’ clinical monitoring usually includes glomerular filtration rate (GFR) evaluation; no study addressed the issue of the early kidney injury. We evaluated the early (within 3 months) effect of iv ZA on renal function defining the potential role of AKI biomarkers in unveiling subtle damage.<p...