Bone Abstracts

Background: Some of the risk factors for osteoporosis population include: chronic immobilisation, insufficient dietary supply of calcium and vitamin D, decreased physical activity and long-term pharmacological treatment (glucocorticoids, anticonvulsant drugs). In disabled children and adolescents, the negative impact of these factors may cumulate to considerably impair the quality of life.Objectives: The aim of our study was to assess the vitamin D statu...

Over 80% of Quebec woman initiate breastfeeding, and rates of exclusive breastfeeding at 6 months doubled from 2003 (9.7%) to 2009 (19.0%). To prevent deficiency, current recommendations for these infants include 400 IU/day of vitamin D. For 20 years, Quebec has offered a program of free vitamin D supplements through its public medication insurance plan (RAMQ).Objective: Program evaluation over the last decade.Methods: This is a re...

Objectives: We have previously described biochemical evidence of resistance to PTH in Indian toddlers, which reversed on calcium supplementation. We performed a post-hoc analysis on data from an RCT of vitamin D and calcium supplementation, which was designed to assess if supplementation would reduce infection rate in undernourished school children with adequate sun exposure. Specifically we investigated the effect of oral vitamin D and calcium supplementation on biochemical p...

One growth factor that potentially plays a role in fracture healing is midkine (Mdk). Mdk is expressed in chondrocytes during bone repair (Ohta et al. 1999) and has been shown to influence bone mass and mechanotransduction (Neunaber et al. 2010, Liedert et al. 2011). The aim of the present study was to evaluate the effects of Mdk-deficiency on bone repair in a standardized mouse femur osteotomy model.Mdk-deficient and wildtype ...

Objective: Muscular dystrophy is characterized by lower skeletal muscle quality, lower muscle strength and physical performance. The aim of the study was to assess regional muscle density and its correlation with regional muscle area in Duchenne muscular dystrophy (DMD) subjects and able bodied controls.Method: Skeletal muscle pQCT (peripheral quantitative computed tomography) scans at the non-dominant forearm were performed in patients with muscle dystr...

Objectives: Previous studies have shown that burden of infections is greater in those with low body stores of vitamin D. Vitamin D is a key mediator of innate immunity and is crucial in production of cathelicidin, a potent antimicrobial agent. Vitamin D deficiency is common among Indian children; the prevalence of infections is high. Thus, aims of our study were to examine the association between: i) serum 25-hydroxyvitamin D (25OHD) concentrations and symptoms of infections a...

Objectives: To evaluate vitamin D and bone mineral density (BMD) status in children with Duchene muscular dystrophy (DMD) in relation to fractures and ambulation status using gross motor scale function classification system (GMFCS).Methods: Clinical data of 53 DMD patients (mean age 12.1 years, range 4.9–19.6) at the first visit to the Endocrine/Bone Clinic at Nationwide Children’s Hospital were retrospectively studied. The patients were strati...

Introduction: Rickets is characterised by defective mineralisation of the growth plate and osteoid, caused by deficiency of vitamin-D and/or of dietary calcium. Rickets continues to be reported in the UK, especially in children from dark-skinned ethnic groups. Literature on the cost of management of rickets and cost-effectiveness of vitamin D supplementation is lacking worldwide.Methods: The analysis considers the cost-effectiveness of an intervention in...

Introduction: Vitamin D is known to be important for bone health. Still, the significance of serum 25-hydroxy vitamin D concentrations (s-25OHD) for hip fracture risk of the elderly is uncertain. Discordant findings may in part be explained by difficulties of RCTs or large cohort studies to reach both the frail and the healthy elderly. The objectives of this study were to determine the risk of hip fractures of the elderly related to s-25OHD, including both the frail and the he...

1,25-Dihydroxyvitamin D (1,25D) is one of the major regulators of calcium metabolism. Due to its lipophilic nature and low circulating concentration, the measurement of 1,25D concentration levels has been labour intensive and technique dependent in addition to multiple equipments required for the sample purification procedure. We reported the results of soon to be commercialised fully on-board IDS-iSYS 1,25 VitDXp assay.IDS-iSYS 1,25 VitD...