Bone Abstracts

Introduction: Cranialfacial fibrous dysplasia (CFD) presents with pain, facial asymmetry and/or neurological complications. It has been suggested that patients with CFD respond favourably to treatment with bisphosphonates, by a decrease in pain and arrest of progression. Therefore, we performed a retrospective study of 56 patients with CFD in our center.Methods: We assessed clinical characteristics and disease course. Furthermore, clinical and biochemica...

Dysosteosclerosis (DSS) is the rare osteopetrosis (OPT) distinguished by metaphyseal osteosclerosis with relative radiolucency of widened diaphyses and platyspondyly. In 2012, mutations in the SLC29A3 gene were discovered to cause DSS.Here, we report a new case of DSS presenting with severe anemia and having a unique homozygous mutation in SLC29A3.Our patient was the 3rd child of consanguineous Turkish parents. She present...

Histomorphometry is often adopted as a methodological approach in research of femoral bone structure. However, it is common do not describe technical details of procedure especially on the steps of macroscopy, paraffin embedding and microtomy. So we propose a simplified, reliable and reproducible method of histological processing for intertrochanteric region and femoral neck of mice, to ensure the achievement of tissue sections with similar structures, cell populations and his...

Purpose: The purpose of this study is to analyse regional differences in the microstructural and mechanical properties of the distal femur depending on osteoarthritic changes using micro-images based on finite element analysis.Materials and methods: Distal femur specimens were obtained from ten donors composed of ten women with OA (mean age of 65 years, ranging from 53 to 79). As controls, the normal distal femur was sampled from age and gender matched d...

Objectives: The purpose of this study is to determine the chemical information in trabecular bone by Raman spectroscopy in the osteoarthritic and non-osteoarthritic distal femur.Materials and methods: Distal femur specimens were obtained from ten donors composed of ten womens with OA (mean age of 63 years, ranging from 50 to 76). As controls, the normal distal femur was sampled from age and gender matched donors consisting of ten womens (mean age of 53 y...

Background and objective: High-resolution magnetic resonance imaging (hrMRI) can assess trabecular bone microarchitecture but the number of image slices required for reliable assessment is unclear.Methods: MRI was performed just below the growth plate of the proximal tibia from 20 healthy controls (all female; median age 21 years (range 18–35) and 10 cases (three mals: seven females; median age 19.5 years (range 16–48) with known bone abnormali...

Cadmium (Cd) is regarded as a risk factor for various bone diseases in humans and experimental animals. To compare effects of different routes of Cd administration on femoral bone structure, ten 4-month-old male Wistar rats (group A) were injected intraperitoneally with a single dose of 2 mg CdCl2/kg body weight and killed 36 h after Cd had been injected. Ten 1-month-old male rats (group B) were dosed with a daily Cd intake of 30 mg CdCl2/l in drinking wa...

Introduction: Fragility fractures are number growing. They reduced quality life and increased mortality. After 50 years, one woman and two men will have an osteoporotic fracture in their lifetime. The presence of a vertebral fracture (VF) multiplied the risk of new vertebral fracture and the risk of hip fracture. They are pauci or asymptomatic.Study purpose: Evaluate the prevalence of fragility vertebral fractures after 50 years, the number of asymptomat...

Introduction: Physical exercises improve muscle strength, aerobic capacity and bone density in patients with rheumatoid arthritis (RA). However, some physicians fear to recommend the intensive exercises. The aim of the study is to compare the efficacy of two 6-month exercise programs in patients with early RA.Methods: Fifty-one patients with early RA were randomized into 3 groups. At hospital stage 15 patients underwent ten high-intensity dynamic exercis...

Introduction: The effectiveness of intravenous pamidronate was assessed independently and in combination with corrective osteotomy surgery for lower extremity deformities in children with osteogenesis imperfecta.Methods: Orthopaedic treatment was conducted in 21 patients with OI (type I–ten patients, type III–11 patients), including 13 males and eight females with mean age 9.4±0.6. All patients received calcium supplements and active forms...