Bone Abstracts

Osteoporotic patients have poor bone quality and high risk of dental and orthopaedic implant failure. Lithium chloride (LICl) has been reported to enhance osteogenesis. However, the role of LiCl in bone formation and implant osseointegration in osteoporotic condition is still unknown. Therefore, we aimed to investigate the effect of LiCl on bone formation and implant osseointegration in osteoporotic rats.Three months old Sprague–Dawley female rats (...

Background: Women with breast cancer (BC) are at high risk for fracture due to the deleterious impact of BC therapies on bone. In China, BC survival is improving as screening and treatment programs expand, however no guidelines exist to prevent BC treatment-induced bone loss. We sought to evaluate the scope of this problem among BC survivors receiving care at a large cancer referral hospital in China.Methods: Women were invited to participate in this cro...

Context: As bone metabolic markers, recent studies indicated vitamin D and osteocalcin (OC) were also involved in energy metabolism. While the exact relationship between vitamin D and OC in regulating energy metabolism is unclear. One of the possibilities is that: low vitamin D could lead to secondary hyperparathyroidism and following high bone turnover, which would enhance the quantity of bioactive OC.Objective: Our aim was to study whether OC mediated ...

Background: At present, clinical assessment of bone strength in children predominantly relies bone mass measurement using absorptiometry (DXA) or QCT densitometric approaches. However, bone strength is not only dependent on mass/density, but also structural and material mechanical properties. Currently no technique measures bone mechanical properties. Recently, a new micro-indentation device, the reference point indentation (RPI) instrument has been validated for the measure o...

The cathepsin K inhibitor odanacatib (ODN) is a bone formation-sparing inhibitor of osteoclastic resorption activity. This drug is currently under development for the treatment of postmenopausal osteoporosis. To support the bone safety profile of ODN, we evaluated the effects of ODN on trabecular bone hard tissue properties in the estrogen-deficient model of the ovariectomized (OVX) rhesus monkeys. Animals (n=16/group, age 11–22 years) were treated immediately af...

Background: There are currently 456 rare bone disease recorded within 40 groups. Within many of these diagnoses there is marked heterogeneity of severity and complications that is often not explained by current understanding of disease mechanisms. There is an urgent need to improve the care of these patients by developing novel diagnostic tests and therapies based on understanding sub-phenotypes within existing diagnostic groups.Aim: To develop a nationa...

Objective: It was proved that expansive pedicle screw (EPS) could significantly enhance immediate screw stability through mechanical expanding and compressing. However, there were little researches on growth of bone tissue around screw and dynamic screw stability in vivo in osteoporotic vertebrae. This study was designed to evaluate growth and microstructure of bone tissue around screw and fixation strength of screw in osteoporotic sheep lumbar vertebrae.<p class=...

Objective: To comparing the role of interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in fat and bone communication.Methods: Male wild type (WT) mice, IL-6 knockout (IL-6−/−) mice, and tumor necrosis factor alpha (TNF-α) were fed with either standard diet (SD) or high fat diet (HFD) for 12 weeks. Bone mass and bone microstructure were evaluated by micro-CT. Gene expression related to lipid and bone metabolisms ...

The effects of dexamethasone on trabecular and cortical bone in OPG−/− mice were investigated in present study. Forty 6-month-old C57BL/6J female mice, including wt (n=20) and OPG knockout (OPG−/−, n=20), were randomdly divided into four groups and treated with either sterile normal saline or dexamethasone at 1 mg/kg by intramuscular injection 3 days per week. All mice were sacrificed at 4 weeks after these treatm...

Objective: The study of melatonin on the levels of autophagy in bone will contribute to new type 2 diabetes osteoporosis-pathological processes by which a specific role and mechanism for the treatment of type 2 diabetes-induced osteoporosis could emerge.Method: This study consists of a two-part experiment. We assessed different body parameters in rats, a type 2 diabetes model application, utilizing different concentrations of melatonin interventions, the...