Bone Abstracts

Objective: We aim to investigate gender similarities and differences in femoral neck (FN) structure of elderly population by bone investigational tookit (BIT) of quantitative computed tomography (QCT).Material and methods: This cross-sectional study was part of China Action on Spine and Hip Status study, including 207 males aged 55–87 years and 400 females aged 55–96 years. QCT scans were performed in the hip for the subjects, and we used BIT s...

The combined effect of lifestyle physical activity (PA) and sedentary behavioral practices on musculoskeletal health in growing populations is still poorly understood. Objectives: To investigate the combined influence of mechanical loading of weight-bearing PA (WBPA) and screen-based sedentary practice (SSR) on musculoskeletal profiles among 455 adolescents aged 12–19 years.Methods: Validated PA and SSR behaviour assessments w...

Short stature and osteoporosis are common in DMD. Disease progression can be slowed by glucocorticoids but these are associated with further growth retardation and skeletal fragility. The defect in growth and skeletal development in children with DMD is probably multifactorial and not solely dependent on glucocorticoid exposure. The muscular dystrophy x-linked (mdx) mouse is the most commonly used animal model of DMD. However, its growth phenotype has not been studied...

Indoxyl sulfate (IS) is one of a number of protein-bound uremic toxins that accumulate in patients with chronic kidney disease. Current conventional hemodialysis is ineffective at removing this toxin. Although IS may impair osteoblast function and induce abnormalities of bone turnover or arthropathy, the effects on knee joint tissue by IS has not been investigated yet. The present studies have been carried out to test the IS effects on synovial fibroblasts, meniscal fibrochond...

The purpose of this study was to investigate the effects of fitness program with vitamin D supplementation for biochemistry related to vitamin D, muscle mass and physical functions in elderly women.The subjects were elderly women aged 65 or older, regularly visiting a senior welfare center and a senior citizen center in city. A total of 65 subjects were divided into experimental group (n=34) and control group (n=31). The intervention fo...

Prostate cancer is a commonly diagnosed malignancy in Europe. Bone is one of the common metastasis sites. There is increasing evidence for estrogen involvement in the prostate tumorigenesis. ERβ knockout (BERKO) mice have been reported to have anti-proliferative, anti-inflammatory and potential anti-tumorigenic functions of ERβ. However, prostate phenotype of BERKO mice has been under debate.The potential effect of ERβ on prostate tumorgen...

Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. RANKL (receptor activator of NF-kB ligand) induces Ca2+ oscillations and activates NFATc1 (nuclear factor of activated T cells i) during osteoclast differentiation. Although Ca2+ oscillations play a key role for osteoclastogenesis...

Backgrounds: Bladder cancer is the most common malignancy and also highest mortality of the urinary tract cancer. Urothelial cell carcinoma (UCC) is the most histopathological subtype of bladder cancer. Epidemiological studies have indicated that bladder cancer risk for cigarette smoking is more than twice than never smoking and that current cigarette smoking triples bladder cancer risk relative to never smoking. Cigarette smoking after bladder cancer diagnosis decreases cance...

Background: There have been many studies on the association between vitamin D and testosterone in the world. But it has not been fully clarified. Furthermore, data in Korean men is limited. This study aimed to determine the association between vitamin D and testosterone levels in korean men.Methods: This cross sectional study analyzed serum 25-hydroxyvitamin D (25(OH)D) and total testosterone in 365 Korean men over 25 years of age who visited a local uni...

Introduction: Osteoporosis is a major bone disease among postmenopausal women. Measurement of BMD in the spine and hip is used as gold standard for the diagnosis of osteoporosis. ISCD recommended that posteroanterior L1-4 as the spine region of interest for BMD measurement. However, both L1-4 and L2-4 are used in the clinical and epidemiological studies. The aim of our study was to evaluate whether the differences of BMD between L1-4 and L2-4 would exist.<p class="abstext"...