Bone Abstracts

Objectives: This study was designed to investigate the prevalence of low bone mass, the influence of amenorrhea on bone mineral density (BMD), and the cause of amenorrhea that provoke the severe low bone mass in premenopausal women.Materials and methods: One hundred and seventy one women diagnosed with amenorrhea in premenopausal women were included in this study. All patients underwent history taking, gynecological examination, and check serum hormone l...

Purpose: The purpose of this study was to scan femoral heads from cadaveric donors and investigate the microarchitecture within each femoral head comprehensively.Material and methods: Ten proximal femora was harvested from eight human cadaveric donors and these specimens were scanned using micro-computed tomography. Reconstructed batches of images were aligned along the main trabecular direction (MTD). The upper hemisphere of each femoral head was includ...

Purpose: Risk factors for intertrochanteric fracture (IF) severity were not studied thoroughly despite the high failure rate of osteosynthesis. The purpose of this study was to identify the risk factor for each fracture type using AO/OTA classification in elderly female patients who experienced IF.Materials and methods: This retrospective study identified 240 women over 50 years old with an incident IF in whom dual-energy x-ray absorptiometry (DEXA) was ...

Objective: The aim of this study was to assess the association between bone mineral density (BMD) and coronary atherosclerosis in healthy postmenopausal women.Methods: We performed a retrospective review of 252 postmenopausal women who visited the health promotion center for a routine checkup, after excluding participants who had factors affecting BMD and coronary artery disease. BMD of the lumbar spine and proximal femur was evaluated by dual-energy X-r...

Objectives: To evaluate risk factors of subsequent vertebral fracture following acute osteoporotic vertebral compression fracture.Methods: As a multicenter retrospective study, we recruited 135 patients treated for acute osteoporotic compression fracture with available spine image taken at 1-year follow-up in three hospitals. The patients were divided into two groups according to occurrence of subsequent vertebral fracture. Two groups were analyzed with ...

Objectives: Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. Receptor activator of NF-κB ligand (RANKL) induces Ca2+ oscillations and activates nuclear factor of activated T cells 1 (NFATc1) during osteoclast differentiation. Although Ca2+ oscillations play a key role for o...

Objective: We aim to investigate gender similarities and differences in femoral neck (FN) structure of elderly population by bone investigational tookit (BIT) of quantitative computed tomography (QCT).Material and methods: This cross-sectional study was part of China Action on Spine and Hip Status study, including 207 males aged 55–87 years and 400 females aged 55–96 years. QCT scans were performed in the hip for the subjects, and we used BIT s...

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily, which functions as bile acid sensor controlling the bile acid homeostasis. We have investigated the role of FXR in regulating bone metabolism in vivo. We have identified expression of FXR in calvaria and bone marrow cells, which was gradually increased during osteoblastic differentiation in vitro. Deletion of FXR in vivo has resulted in significant reduction in bone mineral density by...

Inflammatory processes play a role in osteoclastogenesis. C-reactive protein (CRP), an acute phase reactant that reflects different degree of inflammation. More recently, accumulating evidence suggest that CRP is not only an inflammatory marker but also direct cause of diseases. Therefore, we examined the direct effects of CRP on osteoclast formation using RAW 264.7 cells. CRP significantly inhibited RANKL-induced TRAP-positive multinucleated cell formation in RAW 264.7 cell c...

Growing body of evidence shows that microRNAs play an important role in regulating bone mass. We investigated the cooperative microRNA-mRNA regulatory mechanism of peak bone mass in inbred strain of mice with different bone density using microarray analysis. Femur and tibia of 12-week old C3H/He (high bone density) and C57BL/6 (low bone density) were harvested to extract total bone RNAs for microarray. A total of 30 miRNAs were differentially expressed between bone tissue of C...