Bone Abstracts

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Members of the Rho family including small GTPase Cdc42 have been shown to play multiple roles in cell regulation, including regulation of cytoskeletal organization, cell migration, proliferation, and apoptosis. However, their tissue-specific roles in vivo, especially in limb bud mesenchyme, remain largely unknown. Herein, we report that conditional deletion of Cdc42 in AER dose not change the limb development, however, knockout of Cdc42 in mesenchymal stem cells of li...

Background: In the National Osteoporosis Guide 2014 all the patients are first recommended adequate calcium and vitamin D intake. For additional treatment US FDA approves the use of medications within seven different drug groups, but no magnesium. We have therefore studied the beneficial effect of Mg added to a Ca/vitamin D regime.Study: Fifty healthy women aged above 70 years recruited from elderly center were randomized into a Mg supplementation group ...

Receptor activity modifying proteins (RAMPs 1, 2 and 3) are a class of important accessory proteins that interact and regulate several G-protein coupled receptor (GPCR) activity by finely modulating ligand interaction and in some cases trafficking receptors to cell surface.Predominant roles of RAMPs include ligand selectivity in receptors for Calcitonin (CT) family of peptides that comprise calcitonin, calcitonin gene related peptide, amylin and Adrenome...

The literature has suggested that bone mineral content is modulated by muscle mass and activity. We investigated the relationship between DXA assessed total body bone mineral content, total body lean mass, appendicular lean mass and obesity (a possible marker of inactivity) in a population of 73 boys between the age of 7 and 19 using a Norland XR-46 system.Regression analysis shows that in these growing boys there is a strong positive relationship betwee...

Objectives: To examine the bone mineral density (BMD) response to i.v. pamidronate (Group 1) vs i.v. zoledronic acid (Group 2) in non-ambulatory children and young adults with severe cerebral palsy or other neuromuscular disorders.Methods: A total of 50 non-ambulatory children and young adults, (mean age 11.3 years, range 2.1–32) with low BMD and/or history of fractures were retrospectively studied. Thirty-nine patients (30 spastic quadriplegic cere...

Rationale and hypothesis: In ~70% of advanced prostate cancer (PCa) patients, incurable bone metastases are a significant cause of morbidity and mortality. It has been shown that in models of PCa, bone metastases are initiated by a minor subset (<1% of total cell population) that are mitotically quiescent and which have undergone epithelial to mesenchymal transition (EMT). Recent studies have shown that various P2 receptors regulate invasiveness/EMT in different types of c...

Survival of chronic diseases in childhood is often achieved utilizing glucocorticoids. However, the survival comes at a cost to the growing skeleton, resulting in impairment in the acquisition of peak bone mass and is the major etiology of secondary osteoporosis in children. We recently found that preosteoclasts secrete platelet derived growth factor type BB (PDGF-BB) to promote angiogenesis and osteogenesis during both modeling and remodeling. As glucocorticoid therapy affect...

Context: Primary hyperparathyroidism (PHPT) in children is thought to be extremely rare. We reviewed our experience with PHPT to better characterize these patients.Objective and methods: A total of 62 patients (<18 years) treated in our hospital were respectively analysed to summarize the clinical characterization and molecular genetics in this rare condition in Chinese. The study was approved by the local Ethics Committee of our center.<p class=...

Objectives: Multiple studies have documented the presence of systemic osteopenia in adolescent idiopathic scoliosis and in simulated animal models. Osteopenia was also found to be associated with severe curves and as one of the prognostic factor in predicting curve progression in AIS. The objective of this study was to compare the bone quality and its association with osteopenia between AIS and normal controls.Methods: AIS (n=234) and non-AIS gi...