Bone Abstracts

Introduction: Obesity is the direct cause of a number of immediate problems during childhood. Among them the high prevalence of fractures and joint problems in obese children was observed. Leptin may influence the development and bone remodeling in children, but this phenomenon is not well understood. Therefore, we studied the relationships between leptin and bone turnover markers, growth factors and anthropometric parameters in obese children.Descriptio...

Background: Among body composition phenotypes there is no consensus on definition and consequences of sarcopenic obese phenotype. The recommended method to quantify the muscle mass is the dual energy X-ray absorptiometry (DXA), based on measurement of total fat mass and appendicular lean mass. A high BMI may provide a great bone mineral density (BMD) in many individuals, but it does not guarantee optimal bone strength. The aim of our study is to investigate the influence of sa...

Background: Sarcopenic obesity is usually defined by the combination of sarcopenia and obesity but there is not a standard definition yet. The recommended method for the quantification of muscle mass is dual energy X-ray absorptiometry (DXA), based on assessment of total fat mass and appendicular lean mass. Low Body Mass Index (BMI) used to be considered as a risk factor for fragility fracture. However, recent evidences have demonstrated a correlation between BMI and vertebral...

Background: Higher BMI values are associated with greater bone mineral density (BMD) resulting in a site-specific protective effect for fragility fractures. However, pathophysiologic influence of central adiposity on bone quality may oppose the seemingly positive influence of a greater mechanical loading with higher body masses. The objective of our study was to evaluate the impact of visceral fat on trabecular bone microarchitecture in postmenopausal obese women.<p class=...

Background: An inadequate intake of nutrients, low levels of physical activity, and chronic diseases contribute to reduce muscle mass and physical performance in elderly. WHO reported that number of individuals aged ≥60 years will triple in 2050, with the sub-population aged >85 years that will grow faster than the others. Market of nutraceuticals and dietary supplements is growing in Italy, in particular aimed to improve health in elderly. Objective of this scoping ...

The purpose of this study was to analyze the influence of diet supplemented with hydrosoluble soy extract – HSE in bone mass of male and healthy Wistar rats. Sixteen (16) 30 days old animals were kept in controlled conditions with light/dark cicle and fed with commercial food and filtered water. Randomized into two groups: control group received 500 ml of water and 300 g of food, daily; supplemented group S, in addition of water and food, they also received 500 ml of soy ...

The exposition of shift workers to light at night supresses the melatonin (ME) production. ME supression may contribute to the development of osteoporosis, which can be prevented and treated by resistance exercise (RE). This study evaluated the effect of ME release supression by pineal gland (pinealectomy) and the RE on rats tibiae morphology, mineral quantification and mechanical parameters. The project was approved by the local ethics committee (protocol 2014-00939). Fourty ...

Autosomal dominant hypophosphatemic rickets (ADHR) is a hereditary disorder characterized by isolate renal phosphate wasting, hypophosphatemia, and inappropriately normal 1,25(OH)2D3 levels. ADHR is caused by mutations in FGF23 protein that actively regulates phosphate homeostasis. In contrast to X-linked dominant hypophosphatemic rickets, ADHR shows incomplete penetrance, variable age at onset, and in rare cases resolution of the phosphate-wasting defect...

Objectives: By prospectively evaluating a cohort of girls we aim to identify population patterns linking adipokines and bone turnover during early and late adolescence and to assess the associations of those patterns with forearm bone mineral density (BMD).Methods: The study was developed within a population-based cohort of urban adolescents born in 1990 and assembled in public and private schools of Porto, Portugal (EPITeen). We analysed prospective dat...

see PP212....