Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0004is3 | (1) (1) | ICCBH2015

Bone material properties

Fratzl Peter

Our skeleton needs to carry the body weight and to resist mechanical impacts. This capability or, conversely, bone fragility are controlled by the amount of bone mass, the shape and internal architecture of the bones, as well as by the material of which they are built. Bone material consists of a complex multi-scale arrangement of mineralized collagen fibrils containing also water, proteoglycans as well as some non-collagenous proteins. This organization is by no means constan...
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ba0004is3biog | (1) (1) | ICCBH2015

Bone material properties

Fratzl Peter

Biographical DetailsPeter Fratzl is director at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, and honorary professor at Humboldt University Berlin and Potsdam University. He holds an engineering degree from Ecole Polytechnique in Paris, France, and a doctorate in Physics from the University of Vienna, Austria. His scientific interests include the relation betwee...
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ba0002p163 | (1) | ICCBH2013

Phenotype–genotype correlation and role of ancillary investigations in atypical and rare forms of osteogenesis imperfecta

Balasubramanian Meena , Parker Michael , Bishop Nicholas J

Background: Osteogenesis imperfecta (OI) is a heterogeneous group of inherited disorders of bone formation, resulting in low bone mass and an increased propensity to fracture. It is a variable condition with a range of clinical severity. About 90% of patients with a clinical diagnosis of OI have a mutation in the COL1A1 or COL1A2 genes, which shows an autosomal dominant pattern (AD) of inheritance. Other genes are associated with the autosomal recessive (AR) ...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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ba0004is23 | (1) (1) | ICCBH2015

Multiphoton microscopy

Dondossola Eleonora , Friedl Peter

Multiphoton microscopy (MPM) is a powerful approach to visualize live cells and tissues, including bone, in three dimensions and over time. To enable preclinical longitudinal monitoring of bone by intravital MPM we developed an animal window model of bone using existing tissue engineering strategies. Electrospun polycaprolactone scaffolds and human mesenchymal stem cells after osteoblastic differentiation, in vitro, were implanted into the mouse skin in the presence o...
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ba0004is23biog | (1) (1) | ICCBH2015

Multiphoton microscopy

Dondossola Eleonora , Friedl Peter

Biographical DetailsEleonora Dondossola is a Senior Postdoctoral Fellow in the Intravital Imaging Lab, Koch Center for Applied Research in Genitourinary Cancers, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. She received her PhD in Cell and Molecular Biology from S. Raffaele Vita-Salute University, Milan, Italy, in 2010. Her current research is focused on metastasis...
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ba0004p40 | (1) | ICCBH2015

Painful hip in 19-months old represents an intertrochanteric fracture following a low energy injury

Peev Peter , Obretenov Vasil

Hip fractures in children are extremely rare and account for less than 1% of all fractures in children. Most orthopaedic surgeons will treat only a few such fractures in a lifetime. They are associated with high complication rate because the vascular and osseous anatomy of the child’s proximal femur is vulnerable to injury. Knowledge of the blood supply to the immature proximal femoral epiphysis is necessary to adequately manage these injuries. Hip pain in children is a d...
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ba0004is26 | (1) | ICCBH2015

Duchenne and cerebral palsy

Munns Craig

Childhood and adolescence are critical periods for optimizing bone growth and mineral accrual. Bone strength is determined by bone size, geometry, quality, and mass – variables that are influenced by genetic factors, physical activity, nutrition, and pubertal hormones. Duchenne muscular dystrophy (DMD) and cerebral palsy (CP) are two chronic medical conditions of childhood associated with reduced mobility and increased rate of pathological fracture....
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ba0003pp337 | Osteoporosis: treatment | ECTS2014

Monitoring of calcium intake and vitamin D saturation in Slovak postmenopausal women

Vanuga Peter , Tomkova Sona , Jackuliak Peter , Killinger Zdenko , Payer Juraj

According various guidelines the basic recommendation in prevention and treatment of postmenopausal osteoporosis (PMO) is adequate intake of calcium (1000– 1300 mg/day) and vitamin D (800–1000 IU/day).Aim: To determine the intake dose of calcium and also the vitamin D saturation in women treated for PMO.Patients and methods: 465 women with PMO, divided into two groups: patients with newly diagnosed osteoporosis (n</em...
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ba0001oc5.4 | Treatment of osteoporosis | ECTS2013

Effects of romosozumab administration on trabecular and cortical bone assessed with quantitative computed tomography and finite element analysis

Graeff C , Campbell G , Pena J , Padhi D , Grossman A , Chang S , Libanati C , Gluer C-C

Romosozumab is an investigational bone-forming agent that inhibits sclerostin. Recent data demonstrated that it stimulated bone formation, decreased bone resorption, and led to rapid and substantial increases in areal bone mineral density (BMD; McClung, J Bone Miner Res 27 (S1) S8–S9, 2012). In a Phase 1b, randomized, double-blind, placebo-controlled, multiple dose study, we studied the effects of romosozumab administered for 3 months and follow-...
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Bone Abstracts
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