Bone Abstracts

Bisphosphonates (BPs) are widely used as antiresorptive drugs. However, one of most potent BPs, zoledronic acid (ZA) can cause BP-related osteonecrosis of the jaws (BRONJ) with a poorly understood pathophysiology. The aim of this study was to find a clue for the development of BRONJ by evaluating the cytotoxic effects of ZA on osteoblasts and examining the action mechanism of ZA on osteoclast differentiation. Jaw bone osteoblasts (JB-OBs), long bone osteoblasts (LB-OBs), and b...

Bisphosphonates (BPs) are widely used for treating osteoporosis and preventing osseous metastasis or hypercalcemia in cancers. However, osteonecrosis of the jaw in patients treated with BP after dentoalveolar surgery has been increasing, especially in those treated with strong BPs such as zoledronate (ZA). The pathobiology underlying the occurrence of osteonecrosis only in the jaw bone remains unclear. The objective of this study was to compare the effects of BPs on the in...

Introduction: The correlation between the occurrence of atypical femur fractures (AFFs) and prolonged bisphosphonate use has been reported in many studies. However, the incidence of AFFs is extremely low, which results in the lack of studies illuminating its treatment and clinical results so far. In this study, we aim to elucidate the clinical outcomes of bisphosphonate-associated AFFs and the clinical results depending on the bisphosphonate therapy period.<p class="abstex...

Purpose: Risk factors for intertrochanteric fracture (IF) severity were not studied thoroughly despite the high failure rate of osteosynthesis. The purpose of this study was to identify the risk factor for each fracture type using AO/OTA classification in elderly female patients who experienced IF.Materials and methods: This retrospective study identified 240 women over 50 years old with an incident IF in whom dual-energy x-ray absorptiometry (DEXA) was ...

Growing body of evidence shows that microRNAs play an important role in regulating bone mass. We investigated the cooperative microRNA-mRNA regulatory mechanism of peak bone mass in inbred strain of mice with different bone density using microarray analysis. Femur and tibia of 12-week old C3H/He (high bone density) and C57BL/6 (low bone density) were harvested to extract total bone RNAs for microarray. A total of 30 miRNAs were differentially expressed between bone tissue of C...

Ca2+ signaling and NFATc1 activation are essential for RANKL-induced osteoclast differentiation through the induction of Ca2+ oscillation, calcineurin activation, and translocation of NFATc1 into the nucleus. Homer proteins are scaffold proteins that have been proposed to modulate multiple Ca2+ signaling proteins, including inositol 1,4,5-triphosphate receptors, ryanodine receptors, transient receptor potential channels. In this study, we inves...

Objectives: Recent studies have demonstrated that vitamin K2 (VitK2) induces apoptosis of not only osteoclasts but also rheumatoid arthritis (RA) synovial cells in vitro, while its clinical effect on disease activity of RA remains unknown.Methods: 158 female RA patients (age 62.5 years, duration of disease 14.9 years) who had not been treated with warfarin, biologics, or teriparatide were enrolled in this study. VitK2 (45 mg/day) was administered orally ...

Objectives: Sox9 is a dominant but insufficient transcription factor to induce thorough primary chondrogenesis, so other factors which may induce primary chondrogenesis besides Sox9 have been assumed. The previously reported function of transcription factor Nkx3.2 is to maintain chondrogenic phenotype by suppressing Runx2, while recent studies demonstrated that mouse Nkx3.2 null mice shows severe metaphyseal dysplasia which is similar to that seen in type II collagen a1 (Col2a...

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Introduction: As Korean society have been entered to aging population, osteoporosis is considered one of the most important disease in the elderly. Osteoporotic vertebral compression fractures can affect to patient’s quality of life. But, in Korea, there is few studies about this, so we investigated.Aim: To evaluate the quality of life of patients with vertebral compression fracture.Methods: This study was performed in multice...