Bone Abstracts

Study design: Prospective study.Objectives: The risk factors correlated with actual falls were assessed in patients with lumbar spinal stenosis.Materials and methods: In 201 patients (M:F 65:136) with symptomatic lumbar spinal stenosis, falls history within recent one year was investigated. The factors which were expected correlation with actual falls were evaluated together. Blood chemistry was performed to evaluate serum Vitamin ...

Background: Many studies have demonstrated that waist-to-height ratio (WHtR) correlates with risk factors of coronary artery disease (CAD) better, than the body mass index (BMI). Coronary artery calcification (CAC) is an independent risk factor of atherosclerotic heart disease. However, the association between WHtR and coronary artery calcification scores (CACS) still need to be elucidated. The purpose of this study was to investigate the relationship between WHtR and CACS in ...

Objection: We compared T-scores of each femoral neck and trochanteric area in the neck fracture patients (NFP) and intertrochanteric fracture patients (IFP). Our hypothesis is that T-score of neck portion in NFP is lower than T-score of neck portion in IFP, and vice versa. We evaluate how FRAX probability is meaningful and sensitive in hip fracture patients.Meterials and methods: From April, 2003 to September, 2012, 18...

Biographical DetailsDr Leanne M Ward is an Associate Professor of Pediatrics at the University of Ottawa where she holds a Research Chair in Pediatric Bone Health. She is the Medical Director of the Pediatric Bone Health Clinical and Research Programs at the Children’s Hospital of Eastern Ontario (CHEO) and a pediatric endocrinologist within the Division of Endocrinology and Metaboli...

Biographical DetailsBarbara M Misof is Staff Scientist at the Ludwig Boltzmann Institute of Osteology, Vienna, Austria. She completed her PhD in Physics and Postgraduate Education in Medical Physics at the University of Vienna in 2000. In 2002, she received the Herbert-Czitober-Research Award of the Austrian Society of Bone and Mineral Research. Her areas of interest are bone material pro...

Introduction: The purpose of this prospective study is to investigate whether bisphosphonate-based anti-osteoporosis medication affects fracture healing and clinical outcomes of conservatively treated osteoporotic spinal fractures (OSFs).Method: A total of 105 patients who were diagnosed with acute OSFs were prospectively enrolled. According to their previous medication history, the patients were allocated into group I (n=39, no history of bisph...

Lipid raft microdomains have important role in cellular signaling. Caveolae are a specialized type of lipid rafts that are stabilized by oligomers of caveolin protein. Here we showed that caveolin-1 (Cav-1) is a critical membrane structural protein of osteoclast. In microarray analysis, we found that caveolin-1 was significantly up-regulated by RANKL. Knock-down of Cav-1 in bone marrow derived-macrophage reduced osteoclastogenesis. Consistent with the in vitro results...

Vaspin (visceral adipose tissue-derived serine protease inhibitor) is a newly discovered adipokine that widely participates in diabetes mellitus, polycystic ovarian syndrome and other disorders of metabolism. However, the effect of vaspin on the regulation of osteogenesis and the mechanism responsible are still unclear. Here, we found that vaspin could attenuate the ALP activities, osteocalcin secretion and Runx2 expression in the preosteoblast cell line MC3T3-E1 in a dose-dep...

Growing body of evidence shows that microRNAs play an important role in regulating bone mass. We investigated the cooperative microRNA-mRNA regulatory mechanism of peak bone mass in inbred strain of mice with different bone density using microarray analysis. Femur and tibia of 12-week old C3H/He (high bone density) and C57BL/6 (low bone density) were harvested to extract total bone RNAs for microarray. A total of 30 miRNAs were differentially expressed between bone tissue of C...

Background and objectives: Fracture in rheumatoid arthritis (RA) patient is more frequent than general population. One of the important reasons is use of glucocorticoid (GC) for treatment of RA. In this study, we aimed to identify the effect of GC on fracture of different site.Methods: Among RA patients ≧19 years, we established a retrospective cohort using Korean national healthcare claims database from Jan 2010 to Dec 2010, and then followed up unti...