Bone Abstracts

Several environmental and genetic factors may interfere on bone mass in children. However, the pediatric studies that approach the socioeconomic status and quantitative ultrasound (QUS) parameters are scarce. The aim of this study was to compare the bone mass in girls from 7 to 15 years old of different socioeconomic status. The sample consisted of 860 Brazilian girls (8.95±1.32) of different socioeconomic status. The bone mass parameter, amplitude dependent speed sound (...

The childhood is an important period for bone mass acquisition, and this tissue may be influenced by the nutritional status. However, the relation between the nutritional status and the bone parameters of quantitative ultrasound (QUS) remains unclear. The aim of this study was to verify the influence of nutritional status on bone mass assessed by QUS in male children from 7 to 10 years old. The sample consisted of 461 Brazilians pre-pubertal schoolchildren (8.30±1.13 year...

The quantitative ultrasound (QUS) of the proximal phalanges has been used for the indirect evaluation of bone status. Furthermore, the relative simplicity and non-exposure to radiation, presents advantages for the use of QUS compared to other methods in children and adolescents. The aim of this study was to determine the influence of age and pubertal development on Amplitude Dependent Speed Sound (AD-SoS) assessed by QUS of proximal phalanges in girls and boys aged 10–15 ...

Objectives: To describe two familiar cases of Hajdu–Cheney syndrome, a rare genetic disorder associated with skeletal dysplasia, craniofacial abnormalities, short stature, acro-osteolysis and osteoporosis.Materials and methods: A 51-year-old woman (case 1) presented in our outpatient clinic with pseudo-clubbing of some fingers and toes. She was short (139 cm) and thin (34 kg). She had facial and cranial abnormalities: thin lips, long philtrum, full ...

Objectives: To describe the response to treatment with teriparatide for osteoporosis associated with Hajdu–Cheney syndrome after a follow-up 2 years.Material and methods: A 51-year-old woman presented in our outpatient clinic with pseudo-clubbing of some fingers and toes. She was short (139 cm) and thin (34 kg). She also had some facial and cranial abnormalities: thin lips, long philtrum, full cheeks, micrognathia, short neck, bushy eyebrows and coa...

Osteoporosis is a growing public health problem. As allies have for preventing physical activity, especially resistance training (RT) and hormone replacement. The aim of this study was to analyze the effect of Raloxifene (RLX) and RT in bone metabolism of rats on their aging period. Wistar rats (14–18 months), sham or ovariectomized (OVX) were treated with RLX (1 mg/kg per day) or saline by gavage and subjected to RT or not. The animals were subjected to RT-oriented pract...

Background: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and ultimately declining in bone biomechanical properties. Our main goal was to study the effects of the inflammatory process on the microarchitecture and mechanical properties of bone in the early stages of arthritis development.</p...

In order to examine metabolic and biophysical parameters arising from obesity, male rats were given to drinking 30% sucrose (p/v) for 8 weeks. During the experimental period, animals in the control group (C) consumed higher amounts of food and water, but the body mass was smaller than the group receiving sucrose (S). In this group, the caloric load given to the animals for eight weeks resulted in increased energy consumption, in glycemia and in plasma leptin and abdominal fat....

Phosphorus intake in western countries is high due to abundant consumption of animal protein and also because of the expanding use of highly absorbable food additive phosphate (FAP) salts in food processing. P is essential for hydroxyapatite in bone, but short-term studies have shown that high P, especially FAP, intake has acute negative effects on bone metabolism. In this study, we investigated the associations between dietary P intake and bone turnover markers by using a cro...

Objectives: Gorham-Stout disease (GSD) is a very rare disorder characterized by extensive angiomatous proliferation and progressive osteolysis without new bone formation. Only ~200 patients were reported. The quality of life is very poor since patients display pain, fractures, functional impairment and swelling of the affected regions. The ethiology of GSD is unknown. We aim to investigate the bone phenotype and to identify molecular and cellular defects in GSD patients.<p...