Bone Abstracts

Fibrodysplasia ossificans progressiva (FOP) is a rare debilitating genetic disease characterized by abnormal progressive heterotopic endochondrial ossification of soft tissues. FOP results from mutations in the intracellular domain of the type I BMP receptor ACVR1 (ALK2) the most common of which is R206H. FOP mutations alter the sensitivity of ACVR1 to Activin A from an antagonist to an agonist. We have previously shown that Activin A is necessary and sufficient for driving he...

Background: Osteocalcin has an important role in bone metabolism. Uncarboxylated osteocalcin predicts risk for hip fracture and lower bone mineral density (BMD). Warfarin inhibits carboxylation of osteocalcin, providing a mechanistic link between warfarin and impaired bone metabolism. Studies examining the relationship between warfarin use and BMD have been inconsistent. The goal of this study was to further characterize this relationship.Population: CaM...

Caffeine is a methylxanthine found in many foods and is widely consumed by the human population. Therefore, its effects and mechanisms in various tissues have been widely studied. But despite changing the postnatal bone growth, there are few studies about its effect on growth cartilage. The objective of this study was to evaluate the In vitro effects of caffeine on proliferation, apoptosis and gene transcripts expression of chondrogenic differentiation in growth carti...

Despite the presence of skeletal anomalies in fetuses of female rats treated with caffeine, their effect on bone’s formation and growth have not yet been elucidated. The objective of this study was to evaluate the effects of caffeine on the formation and endochondral bone growth in rats. There had been used 36 Wistar rats distributed among the control group and others treated with caffeine at doses of 25, 50, and 100 mg/kg. Treated groups received caffeine daily throughou...

Caffeine is a methylxanthine found in many foods and is widely consumed by the human population. Therefore, its effects and mechanisms in various tissues have been widely studied. Various bone abnormalities have been observed in fetuses from rats treated with caffeine. But the genesis of these abnormalities is not known. The objective of this study was to verify the metabolism and activity of calvaria osteoblasts from offspring of rats treated with caffeine during pregnancy. T...

Objectives: From late 2015 a new protocol for zoledronic acid was adopted in our centre. This led to many children changing from pamidronate (PAM) to zoledronic acid (ZA) treatment. In a minority of cases the children and/or their families felt strongly that they wanted to change back to PAM. We present the characteristics of that minority and how bone turnover markers (BTMs) and bone mineral densities (BMD) changed whilst on ZA.Method: From Nov 2016 to ...

The effects of prolactin on bone metabolism have been the subjects of several studies. It is believed that prolactin acts directly influencing the synthesis of bone matrix by stimulating the osteoblastic activity, since receptors for this hormone have been identified in osteoblasts and human mesenchymal stem cells (MSCs). However, no study on the effects of prolactin on the osteogenic differentiation of MSCs was found in the literature. The objective of this study was to verif...

The lactation has been considered a cause of bone loss in humans and animals. Studies have shown that during lactation, there is a significant reduction of bone mineral density. Rats at the end of lactation show reduced bone mass. The objective of this study was to verify the effect of lactation under osteogenic potential of bone marrow mesenchymal stem cells (BMMSCs) of female rats. Twelve Wistar rats were distributed among the control and lactating groups. The experiment was...

The exposition of shift workers to light at night supresses the melatonin (ME) production. ME supression may contribute to the development of osteoporosis, which can be prevented and treated by resistance exercise (RE). This study evaluated the effect of ME release supression by pineal gland (pinealectomy) and the RE on rats tibiae morphology, mineral quantification and mechanical parameters. The project was approved by the local ethics committee (protocol 2014-00939). Fourty ...

Osteoclast presents a central role in several inflammatory diseases that are associated to bone destruction. This condition results from increased osteoclastic bone resorption and/or decreased bone formation. Fluoride (F) is widely consumed in the drinking water due to its anticariogenic effect and has been shown to modulate in vivo bone metabolism in a strain-specific dependent manner. It enhances bone formation in 129P3/J mice but not in A/J mice. However, its effec...