Bone Abstracts

Objectives: Children with compromised weight bearing and limited mobility are particularly at risk for fractures with minimal trauma. Unfortunately, they can also present several obstacles that can impede proper dual X-ray absorptiometry (DXA) scan assessment of whole body or spine bone mineral density (BMD). Since the distal femur is the most common site of fracture in those patients, the lateral distal femur (LDF) represents the site that best addresses the challenges of BMD...

Bone loading is a primary determinant of bone strength in later childhood and adulthood. Our understanding of how mechanical stimuli generated by foetal kicking and movements impact skeletal development is still limited. Many studies suggest that a sufficient and balanced supply of energy, proteins, vitamins, calcium, phosphorus, and other nutrients is an essential prerequisite for normal bone development. However, only few studies highlight the contribution of the biomechanic...

Adverse reactions to bisphosphonates are common and thus, most of them are predictable side effects to the drug. Allergic reactions or skin reactions of any type or severity associated with bisphosphonates have been scarcely described in the literature. Allergic and skin reactions to bisphosphonates have been estimated to occur in less than 1% of patients. The mechanism of these reactions is unknown, although it is presumed to be IgE mediated. All of the bisphosphonates share ...

: Inadequately treated hypophosphataemic rickets (HR) in 14-year-old boy: a case reportBackground: HR is a rare cause of short stature associated with limb deformities.Objective: To report the clinical, laboratory and radiologic features of HR in a 14-year-old boy.Presenting problem: We present the case of the 14-year-old boy, with short stature and deformities of extremities, who complained for limb pain and...

Beside the bone mass, structural changes are important determinants of the bone strength. Patients with osteoarthritis (OA) seem protected against femoral neck (FN) fracture. When compared to osteoporosis, FN in OA are characterized by a higher bone mass and a better trabecular microarchitecture (Blain et al., 2008, Boutroy et al., 2011). The presence of microcracks is one of the determinants of the bone strength. The aim of this study was to evaluate the mic...

Fibrodysplasia ossificans progressiva (FOP) is a rare, extremely disabling genetic disorder characterized by progressive heterotopic ossification preceded by episodic inflammatory soft tissue swellings (flare ups) leading to early death. There is no proven effective treatment yet. We aimed to develop an in vitro system to investigate the working mechanism of flare ups induced ossification.Skin biopsies were obtained from four patients with FOP. ...

Fibrodysplasia ossificans progressiva (FOP) is a rare congenital disorder characterized by progressive heterotopic ossification. FOP patients only present great toe malformations at birth. However, as they grow older they develop soft tissue lumps as a result of flare-ups causing the irreversible replacement of skeletal muscle tissue with bone tissue leading to cumulative physical immobility. Classical FOP patients possess a mutation (c.617G>A; R206H) in the activin recept...

Improvements on the overall cure rates for childhood acute lymphoblastic leukemia (ALL) have allowed the cure of over 85% of treated patients. At least 70% of survivors of childhood ALL cancers have substantial morbidities as a result of their treatment. Long term musculoskeletal complications in this population are currently receiving increasing attention because of their negative impact on the quality of life and ability to perform appropriate activities. Our objective was t...

Overall cure rates for childhood acute lymphoblastic leukemia (ALL) have improved allowing the cure of over 85% of patients. At least 70% of survivors of childhood ALL cancers have substantial morbidities as a result of their treatment. There is evidence that survivors of ALL have increased rates of long-term skeletal muscle dysfunction and weakness. Our objective was to determine the percentage of patients with muscle dysfunctions (muscle force, power, endurance, and % of fit...

Background: In postmenopausal osteoporosis, a loss of bone volume due to increased bone turnover is accompanied by a higher volume of bone marrow adipose tissue (BMAT). If this static relationship is based on a functional relationship, BMAT is a potential target for treating osteoporosis. While it is known that estrogen can reduce BMAT, it is still unknown whether raloxifene – a selective estrogen receptor modulator – can also reduce BMAT.Objec...