Bone Abstracts

see PP180....

Denosumab (DMAb) has a unique profile of bone resorption inhibition: CTX decreases rapidly by 3 days and inhibition is released at the end of the 6-month dosing interval, when DMAb serum levels decrease (McClung NEJM 2006). The dynamic CTX inhibition profile is not curtailed by continued treatment. In the 3-year FREEDOM study, CTX values at 6 months were influenced by baseline CTX values and days since the 1st injection (Eastell JBMR 2011). With 3 additional ...

HLA-B27 transgenic rats, developed by inserting into rat genome the gene for HLA-B27, a human Class I major histocompatibility molecule involved in antigen presentation, spontaneously develop arthritis, ankylosing spondylitis, gastrointestinal inflammation, and severe alveolar bone loss, among other signs of a generalized inflammatory response. Clinical manifestations in these rats closely resemble features of HLA-B27–associated diseases in humans. More recently, investig...

Poor bone mineralization remains a major health problem in patients with Thal and has been linked to functional zinc deficiency despite adequate dietary intake. The global etiology of poor bone mineralization includes inadequate dietary intake of calcium and vitamin D, endocrinopathies leading to disturbed calcium homeostasis, dysregulation of the GH–IGF1 axis, and delayed puberty, all resulting in limited growth, decreased bone formation and increased bone resorption. Th...

Objective: Evidence for further reduction of nonvertebral fracture (NVFX) beyond 3 years of antiresorptive therapy is limited. Since long-term denosumab (DMAb) treatment is associated with continuous increases in BMD and sustained fracture reduction, we analyzed the influence of femoral neck (FN) BMD after 3 years on NVFX rates.Methods: Long-term subjects received 7 continuous years of DMAb; cross-over subjects received 3 years of placebo (FREEDOM) and 4...

The term ‘inflammatory bowel disease’ (IBD) describes a chronic and relapsing inflammation. Up to 25% of all patients with IBD develop the disease during childhood and adolescence. IBD is considered one of the most common chronic childhood diseases in the Western world. Besides epidemiologic data, a short overview about disease presentation, diagnostic criteria and current treatment strategies will be given.The etiology of IBD is still unknown ...

Biographical DetailsS Schmidt graduated with a medical degree from the University of Rostock (Germany) in 1996 and received her pediatric training in Germany, Norway and Sweden. Already during this time she became interested in pediatric inflammatory bowel disease and bone mineral density. After residency, she worked as a pediatric gastroenterologist in the region of Gothenburg (Sweden) a...

Numerous studies in adult patients with type 1 diabetes (T1D) described an association with reduced bone mineral density, altered bone geometry and osteoporosis. Epidemiologic data on hip fractures demonstrate an increased risk in a large adult population with T1D. Diabetes is therefore categorized as adversely affecting the skeleton.In children and adolescence observations have been more controversial regarding bone mineral content, bone mineral density...

Biographical DetailsS Bechtold-Dalla Pozza is a Consultant Pediatric Endocrinologist working at the Department of Endocrinology and Diabetology of the Dr von Haunersches Kinderspital, Ludwig-Maximilians University, Munich, Germany. She completed her pediatric training at the department of Pediatrics at the University Children’s Hospital, Munich, following a clinical and research fell...

Objective: To compare whether interval BMD changes in adolescent females that can be detected using conventional dual energy X-ray absorptiometry (DXA) can also be detected using quantitative peripheral quantitative computerized tomography scans (pQCT) and quantitative ultrasound (QUS)of the os calcis.Methods: Two groups of adolescent females were recruited for assessment of BMD changes over an interval of 22–24 months. These included full time coll...