Bone Abstracts

Clinical trials suggest that denosumab (DEN) therapy results in greater increases in bone mineral density (BMD) in treatment-naive patients than in patients switched from bisphosphonates.We retrospectively reviewed charts of all patients treated with DEN at an osteoporosis referral centre in Vancouver, Canada including all patients treated with DEN 60 mg SC every 6 months for 1 year or more, and in whom baseline and follow-up BMDs were available. BMD was...

Background: WHO recommends diagnostic criteria of osteoporosis can be based on double energy absorption of x-ray bone densitometry (DXA), but the DXA method has some limitations such as relatively higher cost, relatively longer detection time, inconvenience in equipment transportation and so on. Quantitative Ultrasound (QUS) method has the potential to diagnose osteoporosis and it is convenient to carry around and low-cost. Asian osteoporosis self-assessment tool (OSTA) is an ...

Objective: The study of melatonin on the levels of autophagy in bone will contribute to new type 2 diabetes osteoporosis-pathological processes by which a specific role and mechanism for the treatment of type 2 diabetes-induced osteoporosis could emerge.Method: This study consists of a two-part experiment. We assessed different body parameters in rats, a type 2 diabetes model application, utilizing different concentrations of melatonin interventions, the...

Bone remodeling and maintenance require a fine balance between bone formation of osteoblasts and resorption of osteoclasts. Therefore, various skeletal disorders cause by imbalanced differentiation and activities of these cells. RANKL (receptor activator of NF-kB ligand) induces Ca2+ oscillations and activates NFATc1 (nuclear factor of activated T cells i) during osteoclast differentiation. Although Ca2+ oscillations play a key role for osteoclastogenesis...

Purpose: Risk factors for intertrochanteric fracture (IF) severity were not studied thoroughly despite the high failure rate of osteosynthesis. The purpose of this study was to identify the risk factor for each fracture type using AO/OTA classification in elderly female patients who experienced IF.Materials and methods: This retrospective study identified 240 women over 50 years old with an incident IF in whom dual-energy x-ray absorptiometry (DEXA) was ...

Introduction: Percutaneous vertebroplasty is a well known surgical method to put the bone cement at osteoporotic vertebrae. There was a few report concerning about bone cement related complication such as dislodgment of injected cement. There are some contradictory study for long term reaction to bone cement in osteoporotic bone, especially injected cement features. This study is to assess the radiographic features of patients who underwent percutaneous vertebroplasty (PVP) in...

Leptin and adiponectin have an opposing relationship in circulation; leptin is higher and adiponectin lower in overweight/obese individuals, and vice versa. Studies showed that both leptin and adiponectin can be either beneficial or harmful to bone depending on the mode of action. The objective was to investigate the association of serum leptin:adiponectin ratio (L:A) with BMD of various skeletal sites and markers of bone turnover in overweight and obese postmenopausa...

The connection between osteoporosis and obesity is becoming a topic of increasing research. The adipocyte-secreted hormones, leptin and adiponectin, may be the mediators between adipose tissue and bone. The aim was to examine the changes in leptin and adiponectin with the weight and body composition (fat and lean mass) change during the 6-months weight loss program. Additionally, the relationship between two adipokines and BMD of various skeletal sites was also examined. Parti...

Vaspin (visceral adipose tissue-derived serine protease inhibitor) is a newly discovered adipokine that widely participates in diabetes mellitus, polycystic ovarian syndrome and other disorders of metabolism. However, the effect of vaspin on the regulation of osteogenesis and the mechanism responsible are still unclear. Here, we found that vaspin could attenuate the ALP activities, osteocalcin secretion and Runx2 expression in the preosteoblast cell line MC3T3-E1 in a dose-dep...

Discordance of T-score is frequently observed and affects to therapeutic strategy in osteoporosis. Z-score discordance in premenopausal women has not been reported yet. In addition, despite of important role of low bone mineral density (BMD) in premenopausal women to predict osteoporotic fracture in postmenopausal age, there are very few reports on the status of low BMD in healthy premenopausal women. To investigate the current status of idiopathic osteoporos...