Bone Abstracts

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Estrogen deficiency promotes bone loss and skeletal muscle dysfunction. Peroxisome proliferator-activated receptor (PPAR) agonists and high-impact exercise both affect musculoskeletal properties. Whereas PPARδ agonists ameliorate training response in muscle, PPARα agonists exert beneficial effects in bone and muscle. In the present study we investigated the effects of the PPARα agonist fenofibrate and high-impact jumping exercise alone and combined in ovariectom...

Objectives: Duchenne muscular dystrophy (DMD) is a rare hereditary X-linked muscular dystrophy affecting approximately 1:5.000 live borne males. The mobility and respiratory complications have been improved by implementing the glucocorticoid treatment in DMD, however, secondary osteoporosis, short stature and delayed puberty emerged as unwanted side-effects of the treatment. We aimed to evaluate the endocrinological complications in boys with DMD followed at our neuromuscular ...

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Senile osteoporosis and age-related osteopenia are associated with decreased osteoblastogenesis and increased bone marrow adipogenesis. The mechanisms controlling the fate determination of osteoblast to adipocyte differentiation of bone marrow stromal cells (BMSC) during aging are not known. We and others previously showed that the cell-cell adhesion molecule N-cadherin (N-Cadh) expressed in osteoblasts controls bone formation, but little is known about its role in BMSC fate d...

Differentiation of osteoclast progenitor cells into mononucleated TRAcP+ pre-osteoclasts occurs in the bone marrow. But how are these cells dispatched to the future bone resorption sites? We hypothesized that the collagen type III/I-rich reticulin network of the bone marrow might provide a structural framework for localization and migration of differentiating pre-osteoclasts towards the bone surface. Therefore, adjacent sections from decalcified paraffin-embedded iliac crest b...

Objectives: Low bone mineral density (BMD) is reported frequently in adult cystic fibrosis (CF) patients but the data is less consistent for children and adolescents. The aim of our study is to describe bone mineral density (BMD) in a group of children over a period of 10 years and to determine if BMD is related to vitamin D level, calcium intake, lung function, height and age.Methods: A retrospective review of 123 DXA scans conducted in 50 children with...

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Wnt factors bind to heparan sulfate chains of syndecans that hence control their distribution in the cell microenvironment and also contribute to the internalization and recycling of the Wnt receptors. Syndecans are therefore likely important Wnt regulators within the bone marrow. Here, we investigated the interactions between Syndecan-2 and Wnt signaling in normal bone cells. We analyzed the effects of 2.3 kb Col1A1 promoter-driven Syndecan-2 overexpression in osteoblasts. Sy...

Renal osteodystrophy encompasses the bone histologic abnormalities seen in patients with chronic kidney disease (CKD). The bone-specific alkaline phosphatase (BALP) isoform B1x is exclusively found in serum of some CKD patients. The aim of this study was to examine the relationship between serum BALP isoforms and histologic abnormalities of bone in patients with CKD on chronic dialysis (CKD-5D).Anterior iliac crest bone samples from 40 CKD-5D patients we...