Bone Abstracts

Introduction: The purpose of this study was to evaluate whether daily treatment with 400 IU vitamin D3 was sufficient to maintain 25-hydroxyvitamin D (25(OH)D) concentrations above 60 nmol/l over a 3-year period. In addition, the study aimed to clarify if any differences existed in serum 25(OH)D between pre-supplemented women and women who already had serum 25(OH)D above 60 nmol/l at screening.Methods: Serum samples drawn from 251 postmenopaus...

Introduction: Norway has one of the highest reported incidences of osteoporotic fracture. Since, bone mineral density (BMD) is a strong predictor of future fracture risk, high peak bone mass achievement is essential. This study is the first to examine BMD in a population-based study including Norwegian adolescents. Here we compare the measured BMD with international reference ranges and explore predictors of BMD in this population.Methods: In 2010–2...

Roundabout receptors are crucial regulators of vessels and axons growth during development. A comparative transcriptomic study between the MDA-MB-231 breast cancer cell line and its osteotropic subpopulation, MDA-B02 cells, has shown an overexpression of ROBO4 receptor. Interestingly, a high ROBO4 expression in primary tumour from patients with breast cancer correlates with poor prognosis and increased risk of bone metastasis relapse. Inoculation of ROBO4 depleted cells in the...

Total thyroidectomy causes postsurgical hypothyroidism (HypoT). Besides HypoT, patients may also develop hypoparathyroidism (HypoPT).The aim of the study was to assess Quality of Life (QoL), muscle function, and bone indices in patients with postsurgical hypothyroidism and hypoparathyroidism (HypoT+PT) as compared to patients with postsurgical HypoT and healthy controls.Age and gender matched patients on treatment for HypoT+PT and ...

We have reported femoral osteopenia in short term-vitamin D restricted rats without deterioration in tibial cortical bone volume (CBV), geometry or strength1. This study aimed to establish the effect of extended vitamin D deficiency in aged rat tibial volume and strength. Female Sprague-Dawley rats (9 m, n=6/group) were fed a diet containing varying vitamin D3 (D) levels (0, 2, 12, and 20 IU/day) with either low (0.1%, LCa) or high (1%, HCa) diet...

Recent studies confirmed the role of WNT16 in bone mineral density (BMD), bone strength and fracture risk. These findings made WNT16 interesting for further genetic and functional studies to clarify its effect on osteoporosis related parameters.A WNT16 candidate gene association study was performed in men from the Odense Androgen Study (OAS). Five tagSNPs and one multimarker test were selected for genotyping to cover most of th...

It is still unknown where from osteoblasts are recruited during remodeling of adult human cancellous bone. Still, it is often suggested that they originate from perivascular osteoprogenitors in the bone marrow (BM). Here we propose also the existence of a layer of osteoprogenitors at the periphery of the BM. This proposal is based on electron and light microscopy of the bone surface and of the neighboring BM in human iliac crest biopsies, where we quantified cell densities, ce...

Background: Sun exposure may be limited in Arctic populations and Greenland Inuit have adapted to the Arctic environment. The influence of chronic low vitamin D level on PTH to uphold a normal serum calcium remains to be elucidated.Objective: To describe the association between PTH and factors known to influence PTH-, including vitamin D (25OHD) and calcium, in Arctic populations.Methods: Inuit and non-Inuit in the capital city Nuu...

We have shown that the bisphosphonate pamidronate (P) given to children <10d post-burn prevents resorptive bone loss and muscle protein breakdown. We have also shown in vitro that Ca modulates the inflammatory response by altering mononuclear cell chemokine production. We hypothesized that P affects muscle protein breakdown by altering cytokine or chemokine concentration directly or indirectly by lowering blood ionized (i) Ca. We retrospectively analysed biomarker...

Background: The traditional Inuit diet in Greenland consists mainly of fish and marine mammals. The marine diet is an important source for vitamin D in Greenland. Vitamin D has anti-inflammatory capacity but markers of inflammation were high in Inuit with a high intake of marine food items. Yet, the effect of vitamin D on inflammation in Inuit remains unsettled.Objectives: To investigate the association between vitamin D and markers of inflammation in a ...